XL-647

• Catalog number
  B2204-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine; Tesevatinib; EXEL-7647; KD-019
• Description
  XL-647 is an orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. It binds to and inhibits several receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4).
• CAS Number
  781613-23-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₅Cl₂FN₄O₂
• Molecular Weight
  491.38
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  10458325
• PubChem CID Link
• SMILES
  CN1CC2CC(CC2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
• InChi
  InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+
• InChi Key
  HVXKQKFEHMGHSL-GOOCMWNKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  XL-647  
• Gene symbol
  MIR647, BCL2L1, BCL11A
• Short name
  XL-647
• Alternative name
  XL-647

Gene info

• Identity
  HGNC:32903
• Gene
  MIR647
• Long gene name
  microRNA 647
• Synonyms gene
  • MIRN647
• Synonyms
  • hsa-mir-647
• Locus
  20q13.33
• Discovery year
  2006-05-17
• Entrez gene record
  693232
• RefSeq identity
  • NR_030377
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:992
• Gene
  BCL2L1
• Long gene name
  BCL2 like 1
• Synonyms
  • BCLX
  • BCL2L
  • Bcl-X
  • bcl-xL
  • bcl-xS
  • PPP1R52
• Synonyms name
  • protein phosphatase 1, regulatory subunit 52
• GenBank acession
  • Z23115
• Locus
  20q11.21
• Discovery year
  1997-10-30
• Entrez gene record
  598
• Pubmed identfication
  • 8358789
• RefSeq identity
  • NM_138578
• Classification
  • BCL2 family
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000032192

Gene info

• Identity
  HGNC:13221
• Gene
  BCL11A
• Long gene name
  BAF chromatin remodeling complex subunit BCL11A
• Synonyms gene
  • EVI9
• Synonyms gene name
  • ecotropic viral integration site 9
  • B-cell CLL/lymphoma 11A (zinc finger protein)
  • B cell CLL/lymphoma 11A
  • BCL11A, BAF complex component
• Synonyms
  • BCL11A-XL
  • BCL11A-L
  • BCL11A-S
  • CTIP1
  • HBFQTL5
  • ZNF856
  • SMARCM1
• GenBank acession
  • AJ404611
• Locus
  2p16.1
• Discovery year
  2001-02-28
• Entrez gene record
  53335
• Pubmed identfication
  • 11719382
  • 18245381
  • 23644491
• RefSeq identity
  • NM_022893
• Classification
  • Zinc fingers C2H2-type
  • BAF complex
• VEGA ID
  OTTHUMG00000129420
• Locus Specific Databases
  • The Globin Gene Server

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