TRPC4AP, NT (TRPC4AP, C20orf188, TRRP4AP, Short transient receptor potential channel 4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein)

• Catalog number
  MBS641529
• Price
  Please ask
• Size
  0,2 mL

• Other size
  please contact us to order other different size
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created.
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  TRPC4AP   TRPC4AP   C20orf188   TRRP4AP   Short   transient   receptor   potential   channel   4-associated   protein   Protein   TAP1   TNF-receptor   ubiquitous   scaffolding/signaling   protein  
• Gene symbol
  TNF, TRPC4AP, TNFRSF1A, TNFRSF1B, LTBR, TAP1, PSMB8-AS1, SEC14L2
• Short name
  TRPC4AP, NT (TRPC4AP, C20orf188, TRRP4AP, Short transient receptor potential channel 4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein)
• Alternative name
  TRPC4AP, NT (TRPC4AP, C20orf188, TRRP4AP, Short transient receptor potential channel 4-associated protein, Protein transporter 1, adenosine triphosphate-binding cassette, sub-family B (multi-drug-resistant/TAP), tumor necrosis factor-receptor ubiquitous scaffolding/signaling protein)
• Alternative to gene target
  transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), ABC17 and ABCB2 and APT1 and D6S114E and PSF-1 and PSF1 and RING4 and TAP1*0102N and TAP1N, TAP1 and IDBG-81568 and ENSG00000168394 and 6890, ATPase activity, Plasma membranes, Tap1 and IDBG-170616 and ENSMUSG00000037321 and 21354, TAP1 and IDBG-628856 and ENSBTAG00000008953 and 524959

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:16181
• Gene
  TRPC4AP
• Long gene name
  transient receptor potential cation channel subfamily C member 4 associated protein
• Synonyms gene
  • C20orf188
• Synonyms gene name
  • chromosome 20 open reading frame 188
  • transient receptor potential cation channel, subfamily C, member 4 associated protein
• Synonyms
  • DKFZP727M231
  • DKFZp586C1223
  • dJ756N5.2
  • TRRP4AP
  • PPP1R158
• Synonyms name
  • protein phosphatase 1, regulatory subunit 158
• GenBank acession
  • AF055022
• Locus
  20q11.22
• Discovery year
  2001-07-17
• Entrez gene record
  26133
• RefSeq identity
  • NM_015638
• Classification
  • Armadillo like helical domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000032319

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:43
• Gene
  TAP1
• Long gene name
  transporter 1, ATP binding cassette subfamily B member
• Synonyms gene
  • ABCB2
• Synonyms gene name
  • transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
• Synonyms
  • PSF1
  • RING4
  • D6S114E
• Locus
  6p21.32
• Discovery year
  1992-06-25
• Entrez gene record
  6890
• Pubmed identfication
  • 1529427
  • 1946428
• RefSeq identity
  • NM_000593
• Classification
  • ATP binding cassette subfamily B
• VEGA ID
  OTTHUMG00000031067
• Locus Specific Databases
  • TAP1base: Mutation registry for TAP1 deficiency
  • IMGT/HLA Database
  • LRG_166

Gene info

• Identity
  HGNC:39758
• Gene
  PSMB8-AS1
• Long gene name
  PSMB8 antisense RNA 1 (head to head)
• Synonyms gene
  • TAPSAR1
• Synonyms gene name
  • TAP1 and PSMB8 antisense RNA 1
• Synonyms
  • XXbac-BPG246D15.8
  • TAP1-AS1
• Locus
  6p21.32
• Discovery year
  2013-07-25
• Entrez gene record
  100507463
• Pubmed identfication
  • 32151711
• RefSeq identity
  • NR_037173
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000140123

Gene info

• Identity
  HGNC:10699
• Gene
  SEC14L2
• Long gene name
  SEC14 like lipid binding 2
• Synonyms gene
  • C22orf6
• Synonyms gene name
  • SEC14 (S. cerevisiae)-like 2
  • SEC14-like 2 (S. cerevisiae)
  • SEC14-like lipid binding 2
• Synonyms
  • TAP
  • SPF
  • KIAA1186
  • KIAA1658
  • TAP1
• Synonyms name
  • supernatant protein factor
  • tocopherol-associated protein 1
• GenBank acession
  • AL096881
• Locus
  22q12.2
• Discovery year
  1999-10-12
• Entrez gene record
  23541
• Pubmed identfication
  • 10829015
  • 17428729
  • 12757856
• RefSeq identity
  • NM_012429
• Classification
  • SEC14 family
• VEGA ID
  OTTHUMG00000151024

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