Recombinant Human FLT3L / Flt3 ligand / FLT3LG Protein (His tag)

  • Catalog number
    PKSH031692-10µg
  • Price
    Please ask
  • Size
    10µg
  • Synonym
    FL;FLT3L;FLT3LG
  • Activity
    Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with mouse Flt-3. The ED50 for this effect is typically 2-11 ng/mL.
  • Sequence
    Thr27-Pro185
  • Fusion tag
    N-His
  • Accession
    P49771-1
  • Expressed Host
    Baculovirus-Insect Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    >95 % as determined by SDS-PAGE
  • Endotoxin
    <1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    20.2 kDa
  • AP Mol Mass
    27 kDa
  • Formulation
    Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4
  • Background
    FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of the hematopoietic progenitors and stem cells. This may help the system to kill cancer cells. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3L controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 -positive classical DCs and their CD103 -positive tissue counterparts.
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Description
    FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    FLT3L   Flt3   ligand   FLT3LG   Protein   His   tag  
  • Gene symbol
    FLT3LG
  • Short name
    Recombinant FLT3L / Flt3 ligand / FLT3LG Protein (His tag)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    His
  • Species
    Human, Humans
  • Alternative name
    Rec. H. sapiens FLT3L / fms-related tyrosine kinase 3 ligand / fms-related tyrosine phosphorylation catalyst 3 ligand Protein (histidine detection labelled)
  • Alternative technique
    rec
  • Alternative to gene target
    fms-related tyrosine kinase 3, CD135 and FLK-2 and FLK2 and STK1, FLT3 and IDBG-19891 and ENSG00000122025 and 2322, transferase activity, nuclei, Flt3 and IDBG-209045 and ENSMUSG00000042817 and 14255, BT.28173 and IDBG-630678 and ENSBTAG00000018572 and 512700
Gene info
  • Identity
  • Gene
  • Long gene name
    fms related receptor tyrosine kinase 3 ligand
  • Synonyms gene name
    • fms-related tyrosine kinase 3 ligand
    • fms related tyrosine kinase 3 ligand
  • GenBank acession
  • Locus
  • Discovery year
    1994-07-21
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Receptor ligands
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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