GNE-7915

Alternative_name

[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
Description

GNE-7915 is a highly potent LRRK2 kinase inhibit
CAS Number

1351761-44-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C19H21F4N5O3
Molecular Weight

443.4
Cell Permeable

Yes
Purity

>98%
Solubilities

DMSO ≤ 14.33 mg/ml
Handling

Protect from air and light
Tag Line

A highly potent LRRK2 kinase inhibit
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD25977005
PubChem CID

58539171
PubChem CID Link
SMILES

CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC
InChi

1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChi Key

XCFLWTZSJYBCPF-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

GNE-7915
Gene symbol

GNE
Short name

GNE-7915
Alternative name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase-7915
Alternative to gene target

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, DMRV and GLCNE and IBM2 and NM and Uae1, GNE and IDBG-65042 and ENSG00000159921 and 10020, hydrolase activity, Cytoplasm, Gne and IDBG-143173 and ENSMUSG00000028479 and 50798, GNE and IDBG-633656 and ENSBTAG00000001142 and 782201

Identity

HGNC:23657
Gene

GNE
Long gene name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms gene
- IBM2
Synonyms gene name
- UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Synonyms
- Uae1
Synonyms name
- bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
GenBank acession
- AF051852
Locus

9p13.3
Discovery year

2003-11-28
Entrez gene record

10020
Pubmed identfication
- 9305887
- 9305888
RefSeq identity
- NM_005476
VEGA ID

OTTHUMG00000019899
Locus Specific Databases
- LRG_1197