Activin A, human recombinant

• Catalog number
  4724-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Inhibin beta-1, FRP, FSH-releasing protein
• Alternative_names
  Inhibin beta-1, FRP, FSH-releasing protein
• Description
  A protein complex enhancing FSH biosynthesis and secretion
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.
• Results
  < 2 ng/mL
• Molecular Weight
  26.2 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Recombinant human Activin A is lyophilized with 0.02% TFA.
• Reconstitution Instructions
  Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
• Background Information
  Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two beta A chains and is not biologically active until the N terminal propeptide is cleaved from each. Human Activin A has 100% amino acid sequence identity to mouse, rat, porcine, bovine and feline proteins. Recombinant human Activin A is a non-glycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.
• Amino acid sequence
  MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Activin  
• Gene symbol
  ACVR2A, ACVR2B, ACVR1C
• Short name
  Activin A, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Activin A, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:173
• Gene
  ACVR2A
• Long gene name
  activin A receptor type 2A
• Synonyms gene
  • ACVR2
• Synonyms gene name
  • activin A receptor, type II
  • activin A receptor, type IIA
• Synonyms
  • ACTRII
• Locus
  2q22.3-q23.1
• Discovery year
  1993-09-17
• Entrez gene record
  92
• Pubmed identfication
  • 1314589
  • 10702675
• RefSeq identity
  • NM_001616
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000150603

Gene info

• Identity
  HGNC:174
• Gene
  ACVR2B
• Long gene name
  activin A receptor type 2B
• Synonyms gene name
  • activin A receptor, type IIB
• Synonyms
  • ActR-IIB
• GenBank acession
  • X77533
• Locus
  3p22.2
• Discovery year
  1997-03-19
• Entrez gene record
  93
• Pubmed identfication
  • 8161782
  • 9621519
• RefSeq identity
  • NM_001106
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000131291

Gene info

• Identity
  HGNC:18123
• Gene
  ACVR1C
• Long gene name
  activin A receptor type 1C
• Synonyms gene name
  • activin A receptor, type IC
• Synonyms
  • ALK7
  • ACVRLK7
• GenBank acession
  • BC022530
• Locus
  2q24.1
• Discovery year
  2003-07-21
• Entrez gene record
  130399
• Pubmed identfication
  • 12063393
• RefSeq identity
  • NM_145259
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000131964

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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