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Human CellExp COMP TSP5 human recombinant

Human CellExp COMP TSP5 human recombinant is available 2 times from Biovision labs

7452-10 | Human CellExp™ COMP/TSP5, human recombinant size: 10 ug | 255.74 USD

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7452-50 | Human CellExp™ COMP/TSP5, human recombinant size: 50 ug | 734.62 USD

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Synonyms COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5.
Alternative_names COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5.
Description A marker of cartilage turnover
Recombinant Yes
Source HEK293 cells
Purity by SDS-PAGE ≥95%
Assay SDS-PAGE
Biological activity Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells, when rhCOMP / Thrombospondin‑5 immobilized at 1 µg/well. More than 45% of ATDC-5 cell adhesion will be induced.
Results Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells, when rhCOMP / Thrombospondin‑5 immobilized at 1 µg/well. More than 45% of ATDC-5 cell adhesion will be induced.
Molecular Weight This protein fused with 6×His tag at the C-terminus, has a calculated MW of 82 kDa. The predicted N-terminus is Gln 21. DTT-reduced Protein migrates as 110-130 kDa due to glycosylation.
Storage Temp. -20°C
Shipping Gel Pack
Shelf Life 12 months
Appearance Lyophilized
Physical form description Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM NaCl, pH 7.5. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Background Information Cartilage oligomeric matrix protein (COMP) also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contain 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCellExp™ COMP/TSP5
Short name CellExp™ COMP/TSP5, recombinant
Technique Recombinant
Species Humans
Alternative name H. sapiens CellExp™ cartilage oli this GO meric matrix protein/TSP5, H. sapiens recombinant
Alternative technique rec
Alternative to gene target cartilage oli this GO meric matrix protein, EDM1 and EPD1 and MED and PSACH and THBS5, COMP and IDBG-38816 and ENSG00000105664 and 1311, heparan sulfate proteoglycan binding, Extracellular, Comp and IDBG-162847 and ENSMUSG00000031849 and 12845, BT.3034 and IDBG-641613 and ENSBTAG00000004630 and 281088
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Human CellExp COMP TSP5 human recombinant - Gentaur.com
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  • CellExp™
  • COMP/TSP5
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