GPR50 (human) - Clone 1A3

Synonym

G-Protein Coupled Receptor 50, Melatonin-Related Receptor, H9
StorageTemperature

+5 ± 3 °C
HOST

Mouse
Clone

1A3
Format

Protein G purified; lyophilized
Species Crossreactivity

human
Application

IHC
Conjugate

NA
Top Categories

Antibodies
Keywords

Monoclonal; primary antibody
Additonal Description

UniProt: Q13585 GPR50 or melatonin-related receptor is a 617 amino acid protein that belongs to the G-protein coupled receptor 1 family, containing one disulfide bond. GPR50 does not bind melatonin and its endogenous ligand is still unknown. Nevertheless, this receptor has been shown to behave as an antagonist of the melatonin receptor MT1. GPR50 has been identified as a genetic risk factor for bipolar disorder and major depression in women, and it has been linked to neurite outgrowth, lipid metabolism, stress response and energy homeostasis and torpor. Its expression seems to be limited to brain, particularly the hypothalamus and pituitary. Application: IHC (p)
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.