anti-Apaf1 Antibody

  • Catalog number
    2015
  • Price
    Please ask
  • Size
    0.02 mg, 0.1 mg
  • Gene info
    Apaf1 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.
  • Gene names
    Apaf1 Antibody: CED4, APAF-1, KIAA0413, Apoptotic protease-activating factor 1
  • Antibodie s label
    unlabelled serum
  • Purity
    Apaf1 Antibody is affinity chromatography purified via peptide column.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Immunoglobulin
    IgG
  • Antigen
    Apaf1 antibody was made against a peptide corresponding to amino acids near the carboxy terminus of human Apaf1. The sequence of the immunogenic peptide differs from that of murine Apaf1 by one amino acid.
  • Immuno application
    ELISA, Western Blot, immuno-histo-chemistry
  • Antibody advice
    Apaf1 antibody can be used for detection of Apaf1 by Western blot at 1 ug/mL. Human heart tissue lysate can be used as positive control and a 130 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 20 ug/mL.
  • Suspention pH azide
    Apaf1 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Keep at
    Apaf1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Works with
    Human, Mouse, Rat
  • Omim nr
    2330015
  • Ncbi nr
    AAC51678
  • KDa
    130 kDa
  • Vial with antibody
    in solution
  • NCBI GENE nr
    317
  • GENE symbol
    APAF1
  • Antigene name
    apoptotic peptidase activating factor 1
  • Source
    Homo sapiens
  • Protein nr
    O14727
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    Apaf1  
  • Gene symbol
    APIP, APAF1
  • Short name
    anti-Apaf1 Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toApaf1 (antibody to-)
  • Alternative technique
    antibodies
  • Alternative to gene target
    apoptotic peptidase activating factor 1, APAF-1 and CED4, APAF1 and IDBG-52364 and ENSG00000120868 and 317, ADP binding, nuclei, Apaf1 and IDBG-185032 and ENSMUSG00000019979 and 11783, APAF1 and IDBG-636787 and ENSBTAG00000021661 and 537782
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    apoptotic peptidase activating factor 1
  • Synonyms gene name
    • apoptotic protease activating factor
    • apoptotic peptidase activating factor
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1998-01-20
  • Entrez gene record
    317
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Apoptosome
    • WD repeat domain containing
    • Caspase recruitment domain containing
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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