EDG1 Antibody

• Catalog number
  N1039-25UG
• Price
  Please ask
• Size
  0.025mg

• Category
  Antibody
• Concentration
  0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  EDG1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 4-6ug/ml
• Notes
  Provided assay concentrations are suggestions only, EDG1 antibody titration may be required for optimal results.
• Added buffer
  1X Phosphate Buffered Saline (PBS), pH 7.4
• Intented use
  This EDG1 antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  1901
• Purity
  Purified by protein A Affinity Chromatography
• Description
  EDG1 (Endothelial differentiation gene 1), also called Sphingosine-1-phosphate receptor 1 (S1PR1) is the G-protein coupled receptor for Sphingosine 1-phosphate (S1P). Via its interaction with S1P, EDG1 is involved in a number of cellular processes. The binding of S1P leads to angiogenesis and tumor cell motility in cancer, and this interaction also participates in the formation of cell-cell adherens junctions. During embryogenesis, it regulates vascularization. EDG1 interacts with the serotonin receptor 5-HT1AR in the central nervous system. It is also a regulator of innate and adaptive immunity by signaling the release of T-cells from lymph nodes.
• Immunogen
  A recombinant protein fragment from the C-terminal portion of human EDG1 was used as the immunogen for this antibody.
• Storage
  Aliquot the EDG1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  EDG1  
• Gene symbol
  S1PR1, HEXIM1
• Short name
  Anti-EDG1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to EDG1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3165
• Gene
  S1PR1
• Long gene name
  sphingosine-1-phosphate receptor 1
• Synonyms gene
  • EDG1
• Synonyms gene name
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
• Synonyms
  • edg-1
  • D1S3362
  • CD363
• GenBank acession
  • M31210
• Locus
  1p21.2
• Discovery year
  1998-05-15
• Entrez gene record
  1901
• Pubmed identfication
  • 2160972
  • 9488656
• RefSeq identity
  • NM_001400
• Classification
  • CD molecules
  • Sphingosine 1-phosphate receptors
• VEGA ID
  OTTHUMG00000010835

Gene info

• Identity
  HGNC:24953
• Gene
  HEXIM1
• Long gene name
  HEXIM P-TEFb complex subunit 1
• Synonyms gene name
  • hexamethylene bisacetamide inducible 1
• Synonyms
  • CLP-1
  • HIS1
  • MAQ1
  • EDG1
• GenBank acession
  • AB021179
• Locus
  17q21.31
• Discovery year
  2005-06-27
• Entrez gene record
  10614
• Pubmed identfication
  • 12119119
  • 12832472
• RefSeq identity
  • NM_006460
• Classification
  • P-TEFb complex subunits
• VEGA ID
  OTTHUMG00000180112

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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