anti-TACE Antibody
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Catalog number1131
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoTACE Antibody: Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a; is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a;. TNF-a; converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
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Gene namesTACE Antibody: CSVP, TACE, NISBD, ADAM18, CD156B, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, ADAM 17
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Antibodie s labelunlabelled serum
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PurityTACE Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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Spicific to80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.
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AntigenTACE antibody was made against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE.
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Immuno applicationELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence, FLOW
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Antibody adviceTACE antibody can be used for detection of TACE by Western blot at 0.5 ug/mL. For immunocytochemistry use 10 ug/mL. For immunofluorescence start at 10 ug/mL.
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Suspention pH azideTACE Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atTACE antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr73747889
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Ncbi nrNP_003174
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KDaPredicted: 93 kDa
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr6868
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GENE symbolADAM17
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Antigene nameADAM metallopeptidase domain 17
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SourceHomo sapiens
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Protein nrP78536
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolADAM17
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Short nameanti-TACE Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toTACE (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase domain 17
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor, alpha, converting enzyme
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-04-10
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Entrez gene record
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Pubmed identfication
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Classification
- ADAM metallopeptidase domain containing
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data