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Human CellExp CD273 B7 DC PD L2 human recombinant

Human CellExp CD273 B7 DC PD L2 human recombinant is available 2 times from Biovision labs

7369-10 | Human CellExp™ CD273 / B7-DC / PD-L2, human recombinant size: 10 ug | 255.74 USD

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7369-50 | Human CellExp™ CD273 / B7-DC / PD-L2, human recombinant size: 50 ug | 712.60 USD

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Synonyms PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Alternative_names PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Description A protein involved in the costimulatory signal essential for T-cell proliferation.
Recombinant Yes
Source HEK293 cells
Purity by SDS-PAGE ≥95%
Assay SDS-PAGE
Biological activity Measured by its binding ability in a functional ELISA. Immobilized rh B7-DC / PD-L2 / CD273 at 1 µg/mL (100 µl/well) can bind rhPDCD-1 with a linear range of 15 - 500 ng/ml.
Results Measured by its binding ability in a functional ELISA. Immobilized rh B7-DC / PD-L2 / CD273 at 1 µg/mL (100 µl/well) can bind rhPDCD-1 with a linear range of 15 - 500 ng/ml.
Molecular Weight This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 23.4 kDa. The predicted N-terminus is Leu 20. DTT-reduced Protein migrates as 35-48 kDa due to glycosylation.
Storage Temp. -20°C
Shipping Gel Pack
Shelf Life 12 months
Appearance Lyophilized
Physical form description Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Background Information Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCellExp™ CD273 B7-DC PD-L2
Short name CellExp™ CD273 / B7-DC / PD-L2, recombinant
Technique Recombinant
Species Humans
Alternative name H. sapiens CellExp™ CD273 / B7-DC / PD-L2, H. sapiens recombinant
Alternative technique rec
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Human CellExp CD273 B7 DC PD L2 human recombinant
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • CellExp™
  • CD273
  • B7-DC
  • PD-L2
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