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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
Soluble in DMSO, Water or Ethanol
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Peptidyl-glutamyl peptide hydrolytic activity is relatively weak.
1. Omura S., et al. (1991) J. Antibiot. 44: 113. 2. Fenteany G., et al. (1995) Science 268: 726
Refer to PubMed
To be tested
To be tested
Representative figure legend
Chemical structure of Lactacystin (SIH-327), a Proteasome inhibitor. CAS #: 133343-34-7. Molecular Formula: C15H24N2O7S. Molecular Weight: 376.4 g/mol. Chemical structure of Lactacystin, a Proteasome inhibitor (SIH-327). CAS # 133343-34-7. Molecular Formula: C15H24N2O7S.
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Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.