GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471 significantly prevents cardiomyocyte differentiation and results in the reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.
Is it cell-permeable?
Is this a salt?
Protect from air and light
Maximum time for storage
DMSO (~40 mg/ml) or EtOH (~10 mg/ml)
For cells, cell lines and tissues in culture till half confluency.