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anti PARP Cleaved Antibody

anti PARP Cleaved Antibody is available 2 times from Biovision labs

3140-100 | anti-PARP (Cleaved) Antibody size: PARP (Cleaved) Antibody | 523.17 USD

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3141-100 | anti-PARP (Cleaved) Antibody size: PARP (Cleaved) Antibody | 523.17 USD

Catalog number 3141-100
Supplier Biovision
Price 523.17 USD
Size PARP (Cleaved) Antibody
Background information: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavege occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
This antibody reacts with: Mouse
Immunogene sequence: Synthetic peptide corresponding to the C-terminus adjacent to Asp214 of mouse PARP
Concentration of antibody: 0.5 mg/ml
Formulation of this antibody: 100 µg (0.5 mg/ml) affinity purified rabbit anti-cleaved PARP polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal
This antibody has been succesfully tested for use in following methods: Western blot, Immunocytochemistry
Recommended usage: Western blot analysis (0.5-4 µg/ml) and immunocytochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The polyclonal anti-cleaved PARP antibody recognizes only the large fragment of PARP (89 kDa) and does not react with the full length PARP.
1. Gene info
Identity 15677
Gene TNKS2
Long gene name tankyrase 2
Synonyms gene name
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms
  • TNKL
  • TANK2
  • PARP-5b
  • PARP-5c
  • PARP5B
  • PARP5C
  • pART6
  • ARTD6
Synonyms name
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2
GenBank acession
  • AF342982
Locus 10q23.32
Discovery year 2001-05-10
Entrez gene record 80351
RefSeq identity
  • NM_025235
Classification
  • Sterile alpha motif domain containing
  • Poly(ADP-ribose) polymerases
  • Ankyrin repeat domain containing
Havana BLAST/BLAT OTTHUMG00000018747
Product images
    #0#.jpegPARP (Cleaved) Antibody
Target of this antibody: PARP
Alternative names of antibody target: PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
Form of antibody: Liquid
Purification method: Affinity purified
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetPARP Cleaved
Short name anti-PARP (Cleaved) Antibody
Technique Antibody, anti
Alternative name antibody to-PARP (Cleaved) (Antibody to)
Alternative technique antibodies
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anti-PARP (Cleaved) Antibody | Technique alternative | 01012
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • PARP
  • Cleaved
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