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Stock availabilitIn Stock
In Stock
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CAS number
133407-82-6
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Description
Proteasome inhibitor
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Molecular weight
475,9 g/mol
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Primary research fields
Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
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Other name
Z-Leu-Leu-Leu-al, MG 132, Z-Leu-leu-leucinal, Benzyloxycarbonyl-leu-leu-leu-aldehyde, Benzyloxycarbonyl-leucyl-leucyl-leucinal, Carbobenzoxyl-leucinyl-leucinyl-leucinal-H, Lll cpd, Z-LLL, Zlll-cho, Zlllal
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C26H41N3O5
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Origin
Synthetic
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Purity pourcentage
>98% (HPLC); Peptide content: 100%
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Soluble in
Soluble in DMSO (45 mg/ml) or DMF (45 mg/ml) or ethanol (45 mg/ml)
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Physical appearance
White powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
462382
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Scientific context
See included datasheet or contact our support service
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Bibliography
Refer to NCBI PubMed
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Release date
30/Aug/2016
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of MG132 (SIH-537), a Proteasome inhibitor. CAS #: 133407-82-6. Molecular Formula: C26H41N3O5. Molecular Weight: 475.9 g/mol. Chemical structure of MG132, a Proteasome inhibitor (SIH-537). CAS # 133407-82-6. Molecular Formula: C26H41N3O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
