Dipeptidylpeptidase IV, human recombinant

• Catalog number
  4710-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  CD26, ADABP, ADCP2, DPPIV, TP103, DPP4, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, CD26 antigen.
• Alternative_names
  CD26, ADABP, ADCP2, DPPIV, TP103, DPP4, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, CD26 antigen.
• Description
  An antigenic enzyme associated with immune regulation, signal transduction and apoptosis.
• Recombinant
  Yes
• Source
  High-5 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Activity Specifications test method
  >20 Units/mg
• Biological activity
  >20 Units/mg
• Unit Definition
  One unit will hydrolyze 1 mmole of p-nitroaniline per minute at pH 8.0 at 37°C using 1mM of Gly-Pro p-nitroanilde as a substrate.
• Molecular Weight
  86.4 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Liquid
• Physical form description
  0.5 mg/ml; Sterile filtered solution containing 20 mM Tris-HCl buffer pH 8.0,100 mM NaCl, 1 mM EDTA and 10 % glycerol.
• Background Information
  DPP4 is a serine exopeptidase and complex enzyme that is expressed on the surface of most cell types as an intrinsic membrane glycoprotein that cleaves X-proline dipeptides from the N-terminus of polypeptides and plays a role in t-cell activation. DPP4 is associated with intracellular signal transduction, apoptosis and involved in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DPP4 Human Recombinant is a single, glycosylated polypeptide chain containing 746 amino acids (aa 39-766) with a C-terminal His-tag and is purified using conventional chromatography techniques.
• Amino acid sequence
  ADP-SRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP-SGRLVPRGSHHHHHH
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Dipeptidylpeptidase  
• Gene symbol
  DPP4, DPP8
• Short name
  Dipeptidylpeptidase IV, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Dipeptidylpeptidase IV, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:3009
• Gene
  DPP4
• Long gene name
  dipeptidyl peptidase 4
• Synonyms gene
  • CD26
  • ADCP2
• Synonyms gene name
  • dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
  • adenosine deaminase complexing protein 2
  • dipeptidyl-peptidase 4
• Synonyms
  • DPPIV
• GenBank acession
  • M74777
• Locus
  2q24.2
• Discovery year
  1990-03-05
• Entrez gene record
  1803
• Pubmed identfication
  • 8101391
• Classification
  • CD molecules
  • DASH family
• VEGA ID
  OTTHUMG00000132056

Gene info

• Identity
  HGNC:16490
• Gene
  DPP8
• Long gene name
  dipeptidyl peptidase 8
• Synonyms gene name
  • dipeptidylpeptidase 8
  • dipeptidyl-peptidase 8
• Synonyms
  • DP8
  • DPRP1
  • MSTP141
  • FLJ14920
  • FLJ20283
  • MGC26191
• Synonyms name
  • dipeptidyl peptidase VIII
  • dipeptidyl peptidase IV-related protein-1
  • prolyl dipeptidase DPP8
• GenBank acession
  • AF221634
• Locus
  15q22.31
• Discovery year
  2001-09-04
• Entrez gene record
  54878
• Pubmed identfication
  • 11012666
• RefSeq identity
  • NM_017743
• Classification
  • DASH family
• VEGA ID
  OTTHUMG00000133150

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products