HER2, Active, Human Recombinant

  • Catalog number
    8011-50
  • Price
    Please ask
  • Size
    50 µg
  • Synonyms
    HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • Alternative_names
    HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • Description
    Active, Human Recombinant Her2 for functional assays.
  • Recombinant
    Yes
  • Source
    E. coli
  • Activity Specifications test method
    > 20 U/mg
  • Biological activity
    > 20 U/mg
  • Results
    > 20 U/mg
  • Unit Definition
    One unit is defined as the amount of enzyme required to produce 1 nmol of ADP per min. at 25°C, pH 7.2
  • Molecular Weight
    ~ 100 kDa protein in SDS-PAGE under reducing conditions (aa 676 - end, N terminal-GST tag)
  • Storage Temp
    -80°C
  • Shipping
    Dry ice
  • Shelf Life
    12 months
  • Concentration
    0.2 mg/ml
  • Appearance
    Liquid
  • Physical form description
    0.2 mg/ml in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol
  • Background Information
    HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis. HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility.
  • Amino acid sequence
    aa 676 - end
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    HER2   Active  
  • Gene symbol
    ERBB2
  • Short name
    HER2, Active, Recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    HER2, functionnal, H. sapiens Rec.
  • Alternative technique
    rec
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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