-
Synonyms
TrkB, neurotrophic tyrosine kinase, receptor, type 2
-
Alternative_names
TrkB, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B
-
Description
A high affinity catalytic receptor for several neurotrophins
-
Recombinant
Yes
-
Source
Baculovirus (Sf9 insect cells)
-
Purity by SDS PAGE
≥80%
-
Assay
SDS-PAGE
-
Activity Specifications test method
The specific activity of TRKB was determined to be 74 nmol /min/mg as per activity assay protocol.
-
Molecular Weight
67.0 kDa
-
Storage Temp
-80°C
-
Shipping
dry ice
-
Shelf Life
12 months
-
Concentration
5µg/50 µl
-
Appearance
Liquid
-
Physical form description
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
-
Background Information
TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.
-
Handling
Centrifuge the vial prior to opening.
-
Usage
For Research Use Only! Not to be used in humans
-
