Target
BAZ2B
Background
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BAZ2B is expressed in heart, skeletal, testis, and pancreatic tissues. A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.4 The full-length protein contains several DNA-targeting domains, including a methyl-CpG binding domain, a DNA-binding DDT domain, and a tandem PHD-bromodomain. This protein product contains the bromodomain of BAZ2B.
Concentration
N/A
Molecular weight
40.2 kDa (2064-2168 aa + NT GST Tag)
Synonym
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant
Other name
Bromodomain Adjacent to Zinc Finger Domain 2B; KIAA1476; WALp4
NCBI gene number
29994
NCBI gene
BAZ2B
Gene source
Human
NCBI number
Q9UIF8
Recombinant
Yes
Source
E. coli
Purification
≥80%
Tested applications
SDS-PAGE, HPLC
Level of endotoxin
N/A
Tested activity
N/A
Biological activity
N/A
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-80°C
Shipping under
dry ice
Physical appearance
Liquid
Physical properties
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
How to reconstitute
N/A
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants
Gene targetBAZ2B
bromodomain
2064-2168
GST-tagged
Short name
BAZ2B bromodomain (2064-2168 aa) (GST-tagged) recombinant
Technique
Recombinant
Species
Human
Alternative name
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), H. sapiens recombinant
Alternative technique
rec
