The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BAZ2B is expressed in heart, skeletal, testis, and pancreatic tissues. A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.4 The full-length protein contains several DNA-targeting domains, including a methyl-CpG binding domain, a DNA-binding DDT domain, and a tandem PHD-bromodomain. This protein product contains the bromodomain of BAZ2B.
40.2 kDa (2064-2168 aa + NT GST Tag)
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant
Bromodomain Adjacent to Zinc Finger Domain 2B; KIAA1476; WALp4
NCBI gene number
Level of endotoxin
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
How to reconstitute
Centrifuge the vial prior to opening.
For Research Use Only! Not to be used in humans
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
BAZ2B bromodomain (2064-2168 aa) (GST-tagged) recombinant
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), H. sapiens recombinant