RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3

• Catalog number
  MBS224287
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [DELTA-LIKE PROTEIN 3]
• Other_names
  [delta-like protein 3 isoform 1; Delta-like protein 3; delta-like protein 3; delta3; drosophila Delta homolog 3; delta-like 3 (Drosophila); Drosophila Delta homolog 3; Delta3]
• Other_gene_names
  [DLL3; DLL3; SCDO1; Delta3]
• Clonality
  Polyclonal
• Reactivity
  Human (Weak)
• Specificity
  This antibody recognises mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  ELISA (EIA), Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus, Oryctolagus cuniculus
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

• Gene target
  DELTA-LIKE   PROTEIN  
• Gene symbol
  AGPAT4, PSMB6, AHCTF1P1, PPM1D, INGX, PSMA6P1, AFF3, LPAR4, TFDP3, PPP1R1C
• Short name
  RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3
• Technique
  anti mouse, Rabbit, Mouse, anti, antibody to, anti mouse antibodies, mouses
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Species
  Mouse, Mouses
• Alternative name
  production species: rabbit antibody to MOUSE DELTA-LIKE PROTEIN 3
• Alternative technique
  rabbit-anti, murine, antibodies

Gene info

• Identity
  HGNC:20885
• Gene
  AGPAT4
• Long gene name
  1-acylglycerol-3-phosphate O-acyltransferase 4
• Synonyms gene name
  • 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
• Synonyms
  • LPAAT-delta
  • dJ473J16.2
• Synonyms name
  • lysophosphatidic acid acyltransferase, delta
• GenBank acession
  • AF156776
• Locus
  6q26
• Discovery year
  2003-11-25
• Entrez gene record
  56895
• Pubmed identfication
  • 26417903
• RefSeq identity
  • NM_020133
• Classification
  • 1-acylglycerol-3-phosphate O-acyltransferases
• VEGA ID
  OTTHUMG00000015966

Gene info

• Identity
  HGNC:9543
• Gene
  PSMB6
• Long gene name
  proteasome 20S subunit beta 6
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 6
  • proteasome subunit beta 6
• Synonyms
  • Y
  • DELTA
• Synonyms name
  • proteasome subunit β1
• GenBank acession
  • BC000835
• Locus
  17p13.2
• Discovery year
  1995-05-03
• Entrez gene record
  5694
• Pubmed identfication
  • 8066462
  • 1888762
• RefSeq identity
  • NM_002798
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000090777

Gene info

• Identity
  HGNC:24620
• Gene
  AHCTF1P1
• Long gene name
  AT-hook containing transcription factor 1 pseudogene 1
• Synonyms gene
  • AHCTF1P
• Synonyms gene name
  • AT hook containing transcription factor 1 pseudogene
  • AT hook containing transcription factor 1 pseudogene 1
• Synonyms
  • ELYS-like
• Locus
  2q24.2
• Discovery year
  2005-06-20
• Entrez gene record
  285116
• RefSeq identity
  • NG_002622

Gene info

• Identity
  HGNC:9277
• Gene
  PPM1D
• Long gene name
  protein phosphatase, Mg2+/Mn2+ dependent 1D
• Synonyms gene name
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D
• Synonyms
  • Wip1
  • PP2C-DELTA
• Synonyms name
  • wild-type p53-induced phosphatase 1
  • protein phosphatase 2C, delta isoform
• GenBank acession
  • U78305
• Locus
  17q23.3
• Discovery year
  1998-10-14
• Entrez gene record
  8493
• Pubmed identfication
  • 9177166
• RefSeq identity
  • NM_003620
• Classification
  • Protein phosphatases, Mg2+/Mn2+ dependent
• VEGA ID
  OTTHUMG00000180052
• Locus Specific Databases
  • LRG_770

Gene info

• Identity
  HGNC:6064
• Gene
  INGX
• Long gene name
  inhibitor of growth family, X-linked (pseudogene)
• Synonyms gene
  • ING2
• Synonyms gene name
  • inhibitor of growth family, member 2
• Synonyms
  • ING1-like
• GenBank acession
  • AF149724
• Locus
  Xq13.1
• Discovery year
  2000-01-20
• Entrez gene record
  27160
• Pubmed identfication
  • 10626813
• VEGA ID
  OTTHUMG00000024051

Gene info

• Identity
  HGNC:17460
• Gene
  PSMA6P1
• Long gene name
  proteasome subunit alpha 6 pseudogene 1
• Synonyms gene
  • PSMA6P
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene
  • proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene 1
• Synonyms
  • PSMA6-LIKE
  • PSMA6Y
• GenBank acession
  • AC010877
• Locus
  Yq11.221
• Discovery year
  2003-02-11
• Entrez gene record
  64596
• Pubmed identfication
  • 9847074
• RefSeq identity
  • NG_002321
• VEGA ID
  OTTHUMG00000036322

Gene info

• Identity
  HGNC:6473
• Gene
  AFF3
• Long gene name
  AF4/FMR2 family member 3
• Synonyms gene
  • LAF4
• Synonyms gene name
  • lymphoid nuclear protein related to AF4
  • AF4/FMR2 family, member 3
• Synonyms
  • MLLT2-like
• GenBank acession
  • U34360
• Locus
  2q11.2
• Discovery year
  1998-03-27
• Entrez gene record
  3899
• Pubmed identfication
  • 8662235
  • 8555498
• RefSeq identity
  • NM_002285
• Classification
  • Super elongation complex
  • AF4/FMR2 family
• VEGA ID
  OTTHUMG00000153011

Gene info

• Identity
  HGNC:4478
• Gene
  LPAR4
• Long gene name
  lysophosphatidic acid receptor 4
• Synonyms gene
  • GPR23
• Synonyms gene name
  • G protein-coupled receptor 23
• Synonyms
  • P2Y9
  • P2Y5-LIKE
  • P2RY9
  • LPA4
• GenBank acession
  • U90322
• Locus
  Xq21.1
• Discovery year
  1996-08-16
• Entrez gene record
  2846
• RefSeq identity
  • NM_005296
• Classification
  • Lysophosphatidic acid receptors
• VEGA ID
  OTTHUMG00000021895
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:24603
• Gene
  TFDP3
• Long gene name
  transcription factor Dp family member 3
• Synonyms gene name
  • transcription factor Dp family, member 3
• Synonyms
  • HCA661
  • E2F-like
  • CT30
• Synonyms name
  • E2F-like protein
  • cancer/testis antigen 30
• GenBank acession
  • AF219119
• Locus
  Xq26.2
• Discovery year
  2004-07-15
• Entrez gene record
  51270
• Pubmed identfication
  • 12097419
• RefSeq identity
  • NM_016521
• Classification
  • Transcription factor Dp family
• VEGA ID
  OTTHUMG00000022433
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:14940
• Gene
  PPP1R1C
• Long gene name
  protein phosphatase 1 regulatory inhibitor subunit 1C
• Synonyms gene name
  • protein phosphatase 1, regulatory (inhibitor) subunit 1C
• Synonyms
  • Inhibitor-1-like
• GenBank acession
  • AF494535
  • BC017943
• Locus
  2q31.3-q32.1
• Discovery year
  2001-06-29
• Entrez gene record
  151242
• Pubmed identfication
  • 11948623
• RefSeq identity
  • NM_001080545
• Classification
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000154326

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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