anti-TNNT1 Antibody

  • Catalog number
    25-740
  • Price
    Please ask
  • Size
    50 ug
  • Gene info
    TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Gene names
    TNNT1, ANM, MGC104241, TNT, NEM5, STNT, TNTS
  • Antibodie s label
    unlabelled serum
  • Purity
    Antibody is purified by peptide affinity chromatography method.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Antigen
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNNT1.
  • Immuno application
    ELISA, Western Blot
  • Antibody advice
    TNNT1 antibody can be used for detection of TNNT1 by ELISA at 1:312500. TNNT1 antibody can be used for detection of TNNT1 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
  • Suspention pH azide
    Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
  • Keep at
    For short periods of storage (days) store at 4 grades C. For longer periods of storage, store TNNT1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
  • Works with
    Human, Mouse
  • Omim nr
    187173288
  • Ncbi nr
    NP_003274
  • KDa
    33 kDa
  • Vial with antibody
    Lyophilized
  • Quantity per ml
    1 mg/ml
  • NCBI GENE nr
    7138
  • GENE symbol
    TNNT1
  • Antigene name
    troponin T type 1 (skeletal, slow)
  • Source
    Homo sapiens
  • Protein nr
    P13805
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    TNNT1  
  • Gene symbol
    TNNT1
  • Short name
    anti-TNNT1 Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toTNNT1 (antibody to-)
  • Alternative technique
    antibodies
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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