NNMT Antibody
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Catalog number6673-100
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PricePlease ask
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Size100 μg
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Antibody TargetNNMT
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Target Alternative NameNicotinamide N-methyltransferase
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Antibody TypePolyclonal
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Species ReactivitiesHuman
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Immunogen SequenceRecombinant protein of human Nicotinamide N-Methyltransferase
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AccessionP40261
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Gene Id4837
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AppearanceColorless liquid
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FormLiquid
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Concentration0.5 mg/ml
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Formulation100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
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PurificationAffinity Purified Antibody
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ApplicationWestern blot
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Positive ControlWestern Blot: Recombinant protein
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Application And UsagesWestern blot: 1-4 µg/ml.
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DescriptionN-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in cancer diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolNNMT
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Short nameNNMT Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameNNMT (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namenicotinamide N-methyltransferase
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GenBank acession
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Locus
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Discovery year1994-04-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- 7BS small molecule methyltransferases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data