MK-1775
-
Catalog number2373-25
-
PricePlease ask
-
Size25 mg
-
-
Alternative_name2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one
-
DescriptionMK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC₅₀ = 5.2 nM). It selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.
-
CAS Number955365-80-7
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₇H₃₂N₈O₂
-
Molecular Weight500.6
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (~80 mg/ml)
-
HandlingProtect from light and moisture
-
Tag LineA WEE 1 kinase inhibitor
-
Storage Condition-20 ̊C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
PubChem CID24856436
-
SMILESCC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
-
InChiInChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,
-
InChi KeyBKWJAKQVGHWELA-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Gene target
-
Gene symbolMVK, STYXL1, MDK, MAPKAPK3, EPCAM
-
Short nameMK-1775
-
Alternative nameMK-1775
-
Gene info
-
Identity
-
Gene
-
Long gene namemevalonate kinase
-
Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1992-10-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameserine/threonine/tyrosine interacting like 1
-
Synonyms gene
-
Synonyms gene name
- dual specificity phosphatase 24 (putative)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2005-01-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- MAP kinase phosphatases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemidkine
-
Synonyms gene
-
Synonyms gene name
- neurite growth-promoting factor 2
-
Synonyms
-
Locus
-
Discovery year1991-07-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameMAPK activated protein kinase 3
-
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-03-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- MAPK activated protein kinases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameepithelial cell adhesion molecule
-
Synonyms gene
-
Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-10-02
-
Entrez gene record
-
Pubmed identfication
-
Classification
- MicroRNA protein coding host genes
- CD molecules
-
VEGA ID
-
Locus Specific Databases