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Antibody Target
TLR5(Toll-like receptor 5)
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Target Alternative Name
Toll Like Receptor 5
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Antibody Type
Polyclonal
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Species Reactivities
Human, Mouse, Rat
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Immunogen Sequence
Synthetic peptide surrounding amino acid 330 of human TLR5
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Accession
O60602
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Gene Id
7100
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
0.5 mg/ml
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Formulation
100 ml protein A purified rabbit anti-TLR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 10% glycerol and 0.02% thimerosal.
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Purification
Affinity purified rabbit IgG
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Application
Western blot
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Application And Usages
Western blot: 1-4 µg
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Description
The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology(TH) domain,which is essential for Toll-induced signal transduction.TLR1,as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride(LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. TLR6 is highly homologous to TLR1, and like other members of TLR family, it induces NFkB Signaling upon activation. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Dot Blot Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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Additional description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translation
anticorps
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Gene target
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Gene symbol
TLR5
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Short name
TLR5(Toll-like receptor 5) Polyclonal Antibody
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Technique
Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Isotype
rabbit IgG
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Alternative name
toll-like receptor 5(Toll-like receptor 5) polyclonal (antibody to-)
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Alternative technique
polyclonals, antibodies
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Alternative to gene target
toll-like receptor 5, MELIOS and SLE1 and SLEB1 and TIL3, TLR5 and IDBG-106840 and ENSG00000187554 and 7100, protein binding, Plasma membranes, Tlr5 and IDBG-259066 and ENSMUSG00000079164 and 53791, TLR5 and IDBG-648348 and ENSBTAG00000000477 and 444870
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