Recombinant Mouse SPN / CD43 Protein (Fc tag) 50µg
-
Catalog number
PKSM040511-50µg
-
Price
Please ask
-
Size
50µg
-
-
Activity
NA
-
Synonym
A630014B01Rik;Cd43;Galgp;Ly-48;Ly48
-
Sequence
Met 1-Gly 248
-
Fusion tag
C-Fc
-
Accession
P15702
-
Expressed Host
HEK293 Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
> 80 % as determined by SDS-PAGE
-
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
49.6 kDa
-
AP Mol Mass
110 kDa
-
Formulation
Lyophilized from sterile PBS, pH 7.4
-
Background
CD43 is an abundantly expressed molecule on the T-cell surface that shows distinct localization to the migrating T-cell uropod and the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-radixin-moesin (ERM) family of actin regulatory proteins. CD43 has a 235-amino acid (aa) extracellular domain, a 23-aa transmembrane domain, and a 123-aa cytoplasmic domain, all encoded by a single exon. The intracytoplasmic region of the protein is necessary to transduce signals; it is rich in potentially phosphorylable threonines and serines but lacks tyrosine residues as well as catalytic activity. CD43 engagement on human peripheral blood T cells and monocytes leads to cell activation and proliferation through the generation of second messengers such as diacylglycerol and inositol phosphates, protein kinase C (PKC) activation and Ca2+ mobilization. In addition, CD43 ligation on human T cells induces the association of CD43 with Src family kinases, presumably through the interaction of their Src homology 3 domain with a proline-rich region of the CD43 intracytoplasmic tail. This molecule has been implicated in T cell activation, enhancing T cell response to allogeneic or mitogenic stimulation and CD43-specific signals have been reported to be sufficient to activate T cells in the absence of T cell receptor (TCR) engagement. In summary, CD43 regulates multiple T-cell functions, including T-cell activation, proliferation, apoptosis, and migration.
-
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
SPN, DEAF1, PPP1R9B
-
Short name
Recombinant Mouse SPN / CD43 Protein (Fc tag) 50µg
-
Technique
Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Host
mouse
-
Label
Fc Tag
-
Species
Mouse, Mouses
-
Alternative name
Rec. Mouse sialophorin / CD43 Protein (fragment c detection labelled) 50µg
-
Alternative technique
rec, murine
-
Alternative to gene target
sialophorin, CD43 and GALGP and GPL115 and LSN, SPN and IDBG-24512 and ENSG00000197471 and 101929889,6693, protein binding, Extracellular, Spn and IDBG-210057 and ENSMUSG00000051457 and 20737, SPN and IDBG-639328 and ENSBTAG00000026326 and 614645
-
Gene info
-
Identity
-
Gene
-
Long gene name
sialophorin
-
Synonyms gene name
- sialophorin (gpL115, leukosialin, CD43)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
1988-08-31
-
Pubmed identfication
-
Classification
-
VEGA ID
Gene info
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
