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3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase HMGCR Polyclonal Antibody

3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase HMGCR Polyclonal Antibody is available 1 time from Bioma labs

CAU23165 | 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Polyclonal Antibody size: 10 μg | 209.19 USD

1. Gene info
Identity5006
GeneHMGCR
Long gene name 3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms gene name
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Locus5q13.3
Discovery year 2001-06-22
Entrez gene record3156
Havana BLAST/BLATOTTHUMG00000102069
2. Gene info
Identity37519
GenePIRC15
Long gene name piwi-interacting RNA cluster 15
Locus3
Discovery year 2009-11-05
Entrez gene record100313848
Pubmed identfication
Classification
  • Piwi-interacting RNA clusters
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedLinalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.
These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.
Hepatic neutral cytosolic cholesteryl ester hydrolase decreased mRNAs for cholesterol 7alpha-hydroxylase, sterol 27-hydroxylase, and HMG-CoA reductase on day 7 after transfection, coinciding with peak hepatic free cholesterol concentrations
Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and 7-dehydrocholesterol reductase.
Docosahexaenoic acid may enhance brain HMG-CoA reductase activity in aged mice.
macrophages from diabetic mice demonstrate increased oxidative stress and increased expression HMG-CoA reductase
renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading.
TSH can regulate the phosphorylation of HMGCR via AMPK.
High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.
To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific HMGCR knockout mice.
Other name HMG-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase
Clonality Polyclonal
Purity Affinity purified. Please contact us for more details
Estimated production time 7-11 business days
Raised in Rabbit
NCBI number Please refer to NCBI
Gene number Please refer to GenBank
Immunogen HMGCR (Ala638~Ala887)
Protein number Please see Uniprot
Stroage recommendation Aliquot and store at -20°C. Minimize freezing and thawing.
Notes For research use only. Not for diagnostic procedures.
Use before 1 year
Storage recommendation Aliquot and store at -20°C. Minimize freezing and thawing.
Shipping requirements Blue ice
Verified reactivity Rattus norvegicus (Rat)
Antibody's concentration 200μg/ml
Supplementary information Applicable secondary antibody is available. Please inquire
Verified applications WB, ICC, IHC-P, IHC-F, ELISA
Properties If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation anticorps
Short name 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Polyclonal Antibody
Technique Polyclonal, Antibody
Alternative name 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) polyclonal (Antibody to)
Alternative technique polyclonals
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