Necrosulfonamide

  • Catalog number
    9635-50
  • Price
    Please ask
  • Size
    50 mg
  • Alternative_name
    (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
  • Description
    Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Unlike Necrostatin-1 (Cat. No. 1864), NSA does not inhibit the necrosis-induced RIP1 and RIP3 interactions.
  • CAS Number
    1360614-48-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₈H₁₅N₅O₆S₂
  • Molecular Weight
    461.47
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>5 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent necroptosis inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    1566236
  • SMILES
    COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]
  • InChi
    InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+
  • InChi Key
    FNPPHVLYVGMZMZ-XBXARRHUSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Necrosulfonamide
  • Alternative name
    Necrosulfonamide
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