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Necrosulfonamide

Necrosulfonamide is available 4 times from Biovision labs

9635-50 | Necrosulfonamide size: 50 mg | 556.3 USD

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9635-10 | Necrosulfonamide size: 2X10 mg | 389.98 USD

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9635-50 | Necrosulfonamide for cell activation size: 50 mg | 462.24 USD

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9635-10 | Necrosulfonamide for cell activation size: 10 mg | 162.87 USD

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Alternate Name/Synonyms (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
Appearance Yellow solid
Formulation N/A
CAS Number 1360614-48-7
Peptide sequence N/A
Molecular Formula C₁₈H₁₅N₅O₆S₂
Molecular Weight 461.47
Purity ≥98% by HPLC
Solubility/Reconstitution Instructions DMSO (>5 mg/ml)
Handling Protect from air and light
Tagline A potent necroptosis inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 36 months
MDL Number N/A
PubChem CID 1566236
Category Biochemicals
Description Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Unlike Necrostatin-1 (Cat. No. 1864), NSA does not inhibit the necrosis-induced RIP1 and RIP3 interactions.
CAS number 1360614-48-7
Molecular weight 461.47
Other name (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; NSA
Molecular formula C₁₈H₁₅N₅O₆S₂
Physical appearance Yellow solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO (>5 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and light
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