MAPK1/3 Antibody
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Catalog numberPA1049
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PricePlease ask
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Size0,1 mg
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Target antigenMAPK1/3
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman, rat Predicted to work with: mouse
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AnalysesWB,IHC-P
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ImmunogenA synthetic peptide corresponding to a sequence at the N-terminus of human MAPK1/3(171-184aa ARVADPDHDHTGFL), identical to the related rat and mouse sequences.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the MAPK1/3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe MAPK1/3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundMAPK1(ERK2) shares high homology with MAPK3(ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein(MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. ERK1/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1/ERK2.
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Related articles1. Bhalla, U. S.; Ram, P. T.; Iyengar, R. : MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023, 2002. 2. Li, L.; Wysk, M.; Gonzalez, F. A.; Davis, R. J. : Genomic loci of human mitogen-activated protein kinases. Oncogene 9: 647-649, 1994.
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Gene NameMAPK1
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Protein NameMitogen-activated protein kinase 1(MAP kinase 1/MAPK 1)
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Gene Full Namemitogen-activated protein kinase 1
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SynonymsERT1|Extracellular signal-regulated kinase 2
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Uniprot IDP28482
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMAPK1
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Short nameMAPK1/3 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative namemitogen-activated protein kinase 1/3 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetmitogen-activated protein kinase 1, ERK and ERK-2 and ERK2 and ERT1 and MAPK2 and p38 and p40 and p41 and p41mapk and p42-MAPK and P42MAPK and PRKM1 and PRKM2, MAPK1 and IDBG-2147 and ENSG00000100030 and 5594, transferase activity, nuclei, Mapk1 and IDBG-137672 and ENSMUSG00000063358 and 26413, MAPK1 and IDBG-637539 and ENSBTAG00000010312 and 327672
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Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 1
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-11-05
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Entrez gene record
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Classification
- Mitogen-activated protein kinases
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data