MAPK1/3 Antibody

• Catalog number
  PA1049
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  MAPK1/3
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat Predicted to work with: mouse
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human MAPK1/3(171-184aa ARVADPDHDHTGFL), identical to the related rat and mouse sequences.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the MAPK1/3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The MAPK1/3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  MAPK1(ERK2) shares high homology with MAPK3(ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein(MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. ERK1/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1/ERK2.
• Related articles
  1. Bhalla, U. S.; Ram, P. T.; Iyengar, R. : MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023, 2002. 2. Li, L.; Wysk, M.; Gonzalez, F. A.; Davis, R. J. : Genomic loci of human mitogen-activated protein kinases. Oncogene 9: 647-649, 1994.
• Gene Name
  MAPK1
• Protein Name
  Mitogen-activated protein kinase 1(MAP kinase 1/MAPK 1)
• Gene Full Name
  mitogen-activated protein kinase 1
• Synonyms
  ERT1|Extracellular signal-regulated kinase 2
• Uniprot ID
  P28482
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MAPK1/3  
• Gene symbol
  MAPK1
• Short name
  MAPK1/3 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  mitogen-activated protein kinase 1/3 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  mitogen-activated protein kinase 1, ERK and ERK-2 and ERK2 and ERT1 and MAPK2 and p38 and p40 and p41 and p41mapk and p42-MAPK and P42MAPK and PRKM1 and PRKM2, MAPK1 and IDBG-2147 and ENSG00000100030 and 5594, transferase activity, nuclei, Mapk1 and IDBG-137672 and ENSMUSG00000063358 and 26413, MAPK1 and IDBG-637539 and ENSBTAG00000010312 and 327672

Gene info

• Identity
  HGNC:6871
• Gene
  MAPK1
• Long gene name
  mitogen-activated protein kinase 1
• Synonyms gene
  • PRKM2
  • PRKM1
• Synonyms
  • ERK
  • ERK2
  • p41mapk
  • MAPK2
• GenBank acession
  • M84489
• Locus
  22q11.22
• Discovery year
  1993-11-05
• Entrez gene record
  5594
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000030508
• Locus Specific Databases
  • LRG_786

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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