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anti-Anti-CD40L (Ruplizumab), Human IgG1 Antibody

anti-Anti-CD40L (Ruplizumab), Human IgG1 Antibody is available 1 time from Biovision labs

A1094-200 | anti-Anti-CD40L (Ruplizumab), Human IgG1 Antibody size: Anti-CD40L (Ruplizumab), Human IgG1 Antibody | 828.59 USD

Catalog number A1094-200
Supplier Biovision
Price 828.59 USD
Size Anti-CD40L (Ruplizumab), Human IgG1 Antibody
1. Gene info
Identity 11935
Gene CD40LG
Long gene name CD40 ligand
Synonyms gene
  • HIGM1
  • IMD3
  • TNFSF5
Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
Synonyms
  • CD40L
  • TRAP
  • gp39
  • hCD40L
  • CD154
Synonyms name
  • CD40 antigen ligand
  • tumor necrosis factor (ligand) superfamily member 5
  • T-B cell-activating molecule
  • TNF-related activation protein
  • hyper-IgM syndrome
GenBank acession
  • X67878
Locus Xq26.3
Discovery year 1989-06-30
Entrez gene record 959
Pubmed identfication
  • 1427881
  • 7678782
RefSeq identity
  • NM_000074
Classification
  • CD molecules
  • Tumor necrosis factor superfamily
Havana BLAST/BLAT OTTHUMG00000022512
Locus Specific Databases
  • CD40Lbase: Mutation registry for X-linked Hyper-IgM syndrome
  • Global Variome shared LOVD
  • LRG_141
Product images
    #Human#.jpg#0#.jpegAnti-CD40L (Ruplizumab), Human IgG1 Antibody
Target of this antibody: CD40LG
Alternative names of antibody target: CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP
Background information: Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531  ± 155 hours.
Antibody host: Recombinant
Clonality of antibody: Monoclonal
Isotype: Human IgG1, kappa
Clone: hu5c8
This antibody reacts with: Human
Immunogene sequence: Human CD40L
Form of antibody: Liquid
Formulation of this antibody: 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification method: Affinity purified using protein A
This antibody has been succesfully tested for use in following methods: Block; FC
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
French translation anticorps
Gene targetAnti-CD40L Ruplizumab IgG1
Short name anti-Anti-CD40L (Ruplizumab) IgG1 Antibody
Technique Antibody, anti
Isotype IgG1
Species Human
Alternative name antibody to-Anti-CD40L (Ruplizumab), H. sapiens IgG1 (Antibody to)
Alternative technique antibodies
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anti-Anti-CD40L (Ruplizumab) IgG1 Antibody | Technique alter
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  • Anti-CD40L
  • Ruplizumab
  • IgG1
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