TIMP-2 Recombinant Protein

• Catalog number
  40-142
• Price
  Please ask
• Size
  0.002 mg, 0.01 mg

• About recombinant protein
  TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.
• Other name of the recombinant
  DDC8, CSC-21K, Metalloproteinase inhibitor 2, TIMP-2
• Recombinant in
  E. coli
• SEQUENCE
  MCSCSPVHPQ QAFCNADVVI RAKAVSEKEV DSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHIT LCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIK RSDGSCAWYR GAAPPKQEFL DIEDP
• Activity
  TIMP - 2 activity was measured by its ability to inhibit human MMP - 1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP - 2 concentration of approximately 0.5 μg/mL, when using an MMP - 1 concentration of 1.6 μg/mL.
• Keep at
  The lyophilized TIMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted TIMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing TIMP-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4507511
• Accession nr
  NP_003246.1
• Pureity
  Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  7077
• Gene name
  TIMP metallopeptidase inhibitor 2
• Source
  Homo sapiens
• Uniprot
  P16035
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  TIMP-2   Protein  
• Gene symbol
  TIMP2
• Short name
  TIMP-2 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  TIMP-2 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11821
• Gene
  TIMP2
• Long gene name
  TIMP metallopeptidase inhibitor 2
• Synonyms gene name
  • tissue inhibitor of metalloproteinase 2
• Synonyms
  • CSC-21K
• Locus
  17q25.3
• Discovery year
  1992-06-18
• Entrez gene record
  7077
• Pubmed identfication
  • 1427908
• RefSeq identity
  • NM_003255
• Classification
  • Tissue inhibitor of metallopeptidases
• VEGA ID
  OTTHUMG00000154517

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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