Lifitegrast

  • Catalog number
    B1917-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid; SAR-1118; SAR 1118; SAR1118; Lifitegrast, Xiidra.
  • Description
    Lifitegrast is a LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It serves as a molecular decoy to block the binding of LFA-1/ICAM-1 and inhibits the downstream inflammatory process
  • CAS Number
    1025967-78-5
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₉H₂₄Cl₂N₂O₇S
  • Molecular Weight
    615.48
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (~ 30 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A LFA-1 (lymphocyte function-associated antigen-1) antagonist
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    11965427
  • SMILES
    CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl
  • InChi
    InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
  • InChi Key
    JFOZKMSJYSPYLN-QHCPKHFHSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Lifitegrast
  • Alternative name
    Lifitegrast
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