Matrix Metalloproteinase 13 (Collagenase 3)
MMP13 plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion
Store at -70°C
Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
matrix metallopeptidase 13 partial
Mentioned in the data sheet
Research area interests
Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type. Among its related pathways are Integrin Pathway and Development_Glucocorticoid receptor signaling.
Recombinant human procollagenase-3 catalytic domain is expressed in E. coli.
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50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2
Available target modification
Matrix Metalloproteinases, matrixins
See the data sheet
For Research Use only.
Recombinants or rec. proteins