KDM1B polyclonal antibody

• Catalog number
  6847-50
• Price
  Please ask
• Size
  50 μl

• Antibody Target
  KDM1B
• Target Alternative Name
  AOF1, LSD2, C6orf193
• Antibody Type
  Polyclonal
• Species Reactivities
  Human.
• Immunogen Sequence
  Polyclonal antibody raised in rabbit against human KDM1B (lysine (K)-specific demethylase 1B) using two KLH conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
• Accession
  Q8NB78
• Gene Id
  221656
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS with 0.05% (W/V) sodium azide.
• Purification
  Whole Anti-Sera
• Application
  ELISA.
• Positive Control
  ELISA: Peptides.
• Application And Usages
  ELISA: 1:500.
• Description
  KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  KDM1B  
• Gene symbol
  KDM1B
• Short name
  KDM1B polyclonal antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Rabbit IgG
• Alternative name
  KDM1B polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:21577
• Gene
  KDM1B
• Long gene name
  lysine demethylase 1B
• Synonyms gene
  • C6orf193
  • AOF1
• Synonyms gene name
  • amine oxidase, flavin containing 1
  • chromosome 6 open reading frame 193
  • amine oxidase (flavin containing) domain 1
  • lysine (K)-specific demethylase 1B
• Synonyms
  • FLJ34109
  • FLJ33898
  • dJ298J15.2
  • bA204B7.3
  • FLJ43328
  • LSD2
• GenBank acession
  • AK125318
• Locus
  6p22.3
• Discovery year
  2003-06-25
• Entrez gene record
  221656
• Pubmed identfication
  • 19407342
  • 19727073
• RefSeq identity
  • NM_153042
• Classification
  • Zinc fingers CW-type
  • Lysine demethylases
• VEGA ID
  OTTHUMG00000014316

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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