G-CSF, human recombinant

• Catalog number
  4094-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSF β, pluripoietin
• Alternative_names
  Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSF β, pluripoietin
• Description
  A cytokine that stimulates the bone marrow to produce granulocytes and stem cells
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 10⁸ units/mg.
• Molecular Weight
  18.8 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 5 mM Sodium Citrate, pH 4.0.
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
• Background Information
  Granulocyte Colony stimulating Factor (G-CSF) is a potent stimulator of bone marrow cells, especially those of neutrophil lineage. In addition, G-CSF can enhance the survival and activate the immunological functions of mature neutrophils. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Gene
  Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  G-CSF  
• Gene symbol
  CSF3, IGHV3-71, HLA-G, NCAPG, CSF2, FOLR3, SNRPG, GNAO1, CSF1, SFTA2
• Short name
  G-CSF, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  G-CSF, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:2438
• Gene
  CSF3
• Long gene name
  colony stimulating factor 3
• Synonyms gene
  • GCSF
  • G-CSF
  • C17orf33
• Synonyms gene name
  • chromosome 17 open reading frame 33
  • colony stimulating factor 3 (granulocyte)
• Synonyms
  • MGC45931
• Synonyms name
  • granulocyte colony stimulating factor
  • pluripoietin
  • filgrastim
  • lenograstim
• Locus
  17q21.1
• Discovery year
  2001-06-22
• Entrez gene record
  1440
• Pubmed identfication
  • 3499671
  • 3501046
• RefSeq identity
  • NM_172220
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000133247

Gene info

• Identity
  HGNC:5621
• Gene
  IGHV3-71
• Long gene name
  immunoglobulin heavy variable 3-71 (pseudogene)
• Synonyms gene
  • IGHV3-G
• Synonyms gene name
  • immunoglobulin heavy variable 3-71
  • immunoglobulin heavy variable 3-G pseudogene (provisional)
  • immunoglobulin heavy variable 3-G (provisional)
  • immunoglobulin heavy variable 3-71 pseudogene
• Synonyms
  • IGHV3-g
• GenBank acession
  • AB019437
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28411
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151881

Gene info

• Identity
  HGNC:4964
• Gene
  HLA-G
• Long gene name
  major histocompatibility complex, class I, G
• Synonyms gene name
  • HLA-G histocompatibility antigen, class I, G
• Synonyms name
  • b2 microglobulin
• Locus
  6p22.1
• Discovery year
  1990-09-10
• Entrez gene record
  3135
• RefSeq identity
  • NM_002127
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031157
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:24304
• Gene
  NCAPG
• Long gene name
  non-SMC condensin I complex subunit G
• Synonyms gene name
  • non-SMC condensin I complex, subunit G
• Synonyms
  • FLJ12450
  • hCAP-G
  • CAP-G
  • YCG1
• Synonyms name
  • chromosome condensation protein G
• GenBank acession
  • AF331796
• Locus
  4p15.31
• Discovery year
  2006-09-04
• Entrez gene record
  64151
• Pubmed identfication
  • 10910072
  • 11136719
• RefSeq identity
  • NM_022346
• Classification
  • Armadillo like helical domain containing
  • Condensin I subunits
• VEGA ID
  OTTHUMG00000128539

Gene info

• Identity
  HGNC:2434
• Gene
  CSF2
• Long gene name
  colony stimulating factor 2
• Synonyms gene name
  • colony stimulating factor 2 (granulocyte-macrophage)
• Synonyms
  • GM-CSF
  • GMCSF
• Synonyms name
  • sargramostim
  • molgramostim
  • granulocyte-macrophage colony stimulating factor
• GenBank acession
  • M11734
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  1437
• Pubmed identfication
  • 3898082
  • 2999978
• RefSeq identity
  • NM_000758
• VEGA ID
  OTTHUMG00000059637

Gene info

• Identity
  HGNC:3795
• Gene
  FOLR3
• Long gene name
  folate receptor gamma
• Synonyms gene name
  • folate receptor 3 (gamma)
  • folate receptor 3
• Synonyms
  • FR-G
  • FRγ
• GenBank acession
  • U08471
• Locus
  11q13.4
• Discovery year
  1997-09-05
• Entrez gene record
  2352
• Pubmed identfication
  • 8110752
• RefSeq identity
  • NM_000804
• VEGA ID
  OTTHUMG00000167870

Gene info

• Identity
  HGNC:11163
• Gene
  SNRPG
• Long gene name
  small nuclear ribonucleoprotein polypeptide G
• Synonyms
  • Sm-G
• GenBank acession
  • X85373
• Locus
  2p13.3
• Discovery year
  1990-06-13
• Entrez gene record
  6637
• Pubmed identfication
  • 7744013
• Classification
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000129670

Gene info

• Identity
  HGNC:4389
• Gene
  GNAO1
• Long gene name
  G protein subunit alpha o1
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
• Synonyms
  • G-ALPHA-o
• Locus
  16q13
• Discovery year
  1988-04-24
• Entrez gene record
  2775
• Pubmed identfication
  • 1899283
  • 11395521
• RefSeq identity
  • NM_020988
• Classification
  • G protein subunits alpha, group i
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133241

Gene info

• Identity
  HGNC:2432
• Gene
  CSF1
• Long gene name
  colony stimulating factor 1
• Synonyms gene name
  • colony stimulating factor 1 (macrophage)
• Synonyms
  • M-CSF
  • MCSF
  • MGC31930
• Synonyms name
  • macrophage colony stimulating factor 1
• GenBank acession
  • BC021117
• Locus
  1p13.3
• Discovery year
  1986-01-01
• Entrez gene record
  1435
• Pubmed identfication
  • 1540160
• RefSeq identity
  • NM_000757
• VEGA ID
  OTTHUMG00000011646

Gene info

• Identity
  HGNC:18386
• Gene
  SFTA2
• Long gene name
  surfactant associated 2
• Synonyms gene
  • SFTPG
• Synonyms gene name
  • surfactant associated protein G
• Synonyms
  • SP-G
• GenBank acession
  • AY102070
• Locus
  6p21.33
• Discovery year
  2002-05-01
• Entrez gene record
  389376
• Pubmed identfication
  • 22768197
  • 23094088
• RefSeq identity
  • NM_205854
• VEGA ID
  OTTHUMG00000031183

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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