MIP-1 alpha Recombinant Protein
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Catalog number
40-337
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Price
Please ask
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Size
0.002 mg, 0.01 mg
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About recombinant protein
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
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Other name of the recombinant
Mip1a, Scya3, G0S19-1, AI323804, MIP1-(a), LD78alpha, MIP-1alpha, MIP1-alpha, Mip1a, C-C motif chemokine 3, Heparin-binding chemotaxis protein, MIP-1-alpha
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Recombinant in
E. coli
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SEQUENCE
APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA
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Activity
Biological activity was determined by its ability to chemoattract murine balb/c splenocytes using a concentration range of 10.0 - 100.0 ng/mL.
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Keep at
The lyophilized MIP-1 alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted MIP-1 alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing MIP-1 alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
6755432
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Accession nr
NP_035467.1
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Pureity
Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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About
This product is for research use only.
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Protein s origin
Murine
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Vial
Lyophilized
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NCBI ID
20302
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Gene name
chemokine (C-C motif) ligand 3
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Source
Mus musculus
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Uniprot
P10855
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Description
The MIP-1 alpha Recombinant Protein is a α- or alpha protein sometimes glycoprotein present in blood.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
Ccl3
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Short name
MIP-1 alpha Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative name
MIP-1 a Rec. Protein
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
CCL3 antisense RNA 1
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Locus
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Discovery year
2020-09-16
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Entrez gene record
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Classification
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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