FTI-277 hydrochloride

• Catalog number
  2874-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
• Description
  FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 blocks constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells.
• CAS Number
  180977-34-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₉N₃O₃S₂.HCl
• Molecular Weight
  484.07
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent and selective farnesyltransferase (FTase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  3005532
• PubChem CID Link
• SMILES
  CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl
• InChi
  InChI=1S/C22H29N3O3S2.ClH/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);1H/t16-,20+;/m1./s1
• InChi Key
  PIAFFJUUNXEDEW-PXPMWPIZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  FTI-277   hydrochloride  
• Short name
  FTI-277 hydrochloride
• Alternative name
  FTI-277 hydrochloride

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