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FTI 277 hydrochloride

FTI 277 hydrochloride is available 4 times from Biovision labs

2874-5 | FTI-277 hydrochloride size: 5 mg | 304.88 USD

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2874-25 | FTI-277 hydrochloride size: 25 mg | 696.05 USD

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2874-25 | FTI-277 hydrochloride for cell activation size: 25 mg | 627.02 USD

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2874-5 | FTI-277 hydrochloride for cell activation size: 5 mg | 201.34 USD

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Description FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 blocks constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells.
Peptide sequence N/A
CAS number 180977-34-8
Molecular weight 484.07
Category Biochemicals
Other name N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
Molecular formula C₂₂H₂₉N₃O₃S₂.HCl
Physical appearance Off-white solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO (>50 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and moisture
Alternate Name/Synonyms N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
Appearance Off-white solid
Formulation N/A
CAS Number 180977-34-8
Molecular Formula C₂₂H₂₉N₃O₃S₂.HCl
Molecular Weight 484.07
Purity ≥98% by HPLC
Solubility/Reconstitution Instructions DMSO (>50 mg/ml)
Handling Protect from air and moisture
Tagline A potent and selective farnesyltransferase (FTase) inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 36 months
MDL Number N/A
PubChem CID 3005532
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