BBS4 (1292CT845.130.218) Monoclonal Antibody

• Catalog number
  bsm-51256M
• Price
  Please ask
• Size
  0.1ml

• Long name
  BBS4 (1292CT845.130.218) Monoclonal Antibody
• Also known as
  BBS4 (1292CT845.130.218) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  BBS4
• Specificity
  This is a highly specific antibody against BBS4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  1292CT845.130.218
• Source
  This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4.
• Gene ID number
  585
• Swiss Prot
  Q96RK4
• Tested Applications
  WB
• Recommended dilutions
  WB(1:1000)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Bardet-Biedl syndrome 4 protein; BBS4
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  BBS4   1292CT845   130   218   Monoclonal  
• Gene symbol
  BBS4
• Short name
  Anti-BBS4
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1
• Alternative name
  BBS4 (1292CT845.130.218) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  Bardet-Biedl syndrome 4, BBS4 and IDBG-20881 and ENSG00000140463 and 585, beta-tubulin binding, multiple, Bbs4 and IDBG-172547 and ENSMUSG00000025235 and 102774, BBS4 and IDBG-645611 and ENSBTAG00000007614 and 532120

Gene info

• Identity
  HGNC:969
• Gene
  BBS4
• Long gene name
  Bardet-Biedl syndrome 4
• GenBank acession
  • AF090947
• Locus
  15q24.1
• Discovery year
  1995-07-11
• Entrez gene record
  585
• Pubmed identfication
  • 7711739
  • 11381270
  • 30665891
• RefSeq identity
  • NM_033028
• Classification
  • BBSome
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000133510
• Locus Specific Databases
  • Mutations of the Bardet-Biedl Syndrome Type 4 Gene

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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