Recombinant Human IL17RD Protein (His tag)

• Catalog number
  PKSH031563-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  HH18;IL-17RD;IL17RLM;SEF
• Activity
  NA
• Sequence
  Met 1-Arg 299
• Fusion tag
  C-His
• Accession
  NP_060033.3
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  33.5 kDa
• AP Mol Mass
  55-60 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of interleukine-17 recepter family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, IL-17RD is expressed in the tongue and in the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL-17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD is able to affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. In addition, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL17RD   Protein   His   tag  
• Gene symbol
  IL17RD
• Short name
  Recombinant IL17RD Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens interleukin 17 receptor D Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  interleukin 17 receptor D, IL17RD and IDBG-41013 and ENSG00000144730 and 54756, protein binding, nuclei, Il17rd and IDBG-140856 and ENSMUSG00000040717 and 171463, IL17RD and IDBG-645321 and ENSBTAG00000010999 and 782214

Gene info

• Identity
  HGNC:17616
• Gene
  IL17RD
• Long gene name
  interleukin 17 receptor D
• Synonyms
  • SEF
  • IL17RLM
  • FLJ35755
  • IL-17RD
• Synonyms name
  • similar expression to fgf genes
• GenBank acession
  • AF494208
• Locus
  3p14.3
• Discovery year
  2003-07-07
• Entrez gene record
  54756
• Pubmed identfication
  • 11802164
  • 12604616
  • 31175175
• RefSeq identity
  • NM_017563
• Classification
  • TIR domain containing
  • Interleukin receptors
• VEGA ID
  OTTHUMG00000150171

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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