RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)

  • Catalog number
    MBS224276
  • Price
    Please ask
  • Size
    5x0.1 mg
  • Products_type
    Antibody
  • Products_short_name
    [ATG5-ATG12 COMPLEX]
  • Other_names
    [ubiquitin-like protein ATG12 isoform 1; Ubiquitin-like protein ATG12; ubiquitin-like protein ATG12; ATG12 autophagy related 12 homolog; Apg12 (autophagy, yeast) homolog; autophagy related 12; Autophagy-related protein 12; APG12-like]
  • Products_gene_name
    [ATG5-ATG12]
  • Other_gene_names
    [ATG12; ATG12; APG12; FBR93; APG12L; HAPG12; APG12; APG12L; APG12-like]
  • Clonality
    Polyclonal
  • Reactivity
    Human
  • Specificity
    This item specifically recognises an epitope within the C-Terminal (CT) region of the Atg5-Atg12 complex, which plays a key role in the regulation of autophagy, and is emerging as an important factor in the innate immune response to viruses. Studies have shown that the Atg5-Atg12 complex directly interacts with RIG-1 (retinoic acid-inducible gene 1) and the adaptor molecule IPS-1 (IFN-beta promoter stimulator 1), through caspase recruitment domains (CARDs), thereby acting as a negative regulator of the type I IFN production pathway, and as a contributor to RNA viral replication within the host cells.
  • Form
    Purified Purified IgG - liquid
  • Concentration
    IgG concentration 1.0mg/ml
  • Storage_stability
    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
  • Tested_application
    Western Blot (WB)
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
  • Gene symbol
    ATG12, ATG5
  • Short name
    RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    IgG
  • Alternative name
    production species: rabbit antibody to autophagy related 5-ATG12 aggregate (C-TERMINAL)
  • Alternative technique
    rabbit-anti, antibodies
  • Alternative to gene target
    autophagy related 5, APG5 and APG5-LIKE and APG5L and ASP and hAPG5, ATG5 and IDBG-94856 and ENSG00000057663 and 9474, protein binding, Plasma membranes, Atg5 and IDBG-148568 and ENSMUSG00000038160 and 11793, ATG5 and IDBG-631895 and ENSBTAG00000005400 and 532686
Gene info
  • Identity
  • Gene
  • Long gene name
    autophagy related 12
  • Synonyms gene
  • Synonyms gene name
    • Apg12 (autophagy 12, S. cerevisiae)-like
    • APG12 autophagy 12-like (S. cerevisiae)
    • ATG12 autophagy related 12 homolog (S. cerevisiae)
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1999-10-01
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Autophagy related
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    autophagy related 5
  • Synonyms gene
  • Synonyms gene name
    • APG5 (autophagy 5, S. cerevisiae)-like
    • APG5 autophagy 5-like (S. cerevisiae)
    • ATG5 autophagy related 5 homolog (S. cerevisiae)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-09-16
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Autophagy related
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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