Anti-NFkB Inducing Kinase NIK, ALEXA Fluor 594

• Catalog number
  GENTObs-0074R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  NFkB Inducing Kinase NIK
• Specificity
  This antibody reacts specifically with NFkB Inducing Kinase NIK
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm
• Antigen Source
  KLH conjugated synthetic peptide derived from human NIK
• Gene ID
  9020
• Swiss Prot
  Q99558
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  HS; NIK; HSNIK; FTDCR1B; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK; MAP3K14
• Also known as
  NFkB Inducing Kinase NIK Antibody
• Other name
  Anti-NFkB Inducing Kinase NIK
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Gene
  NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory

• Gene target
  NFkB   Kinase   NIK  
• Gene symbol
  MAP4K4, MAP3K14
• Short name
  Anti-NFkB Inducing Kinase NIK
• Technique
  anti-, anti, antibody to, antibodies
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  NFkB Inducing Kinase NIK Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6866
• Gene
  MAP4K4
• Long gene name
  mitogen-activated protein kinase kinase kinase kinase 4
• Synonyms
  • HGK
  • NIK
  • FLH21957
• Synonyms name
  • HPK/GCK-like kinase
  • hepatocyte progenitor kinase-like/germinal center kinase-like kinase
• GenBank acession
  • AF096300
• Locus
  2q11.2
• Discovery year
  1999-09-07
• Entrez gene record
  9448
• Pubmed identfication
  • 9890973
  • 9734811
  • 9135144
• RefSeq identity
  • NM_004834
• Classification
  • Mitogen-activated protein kinase kinase kinase kinases
• VEGA ID
  OTTHUMG00000155394

Gene info

• Identity
  HGNC:6853
• Gene
  MAP3K14
• Long gene name
  mitogen-activated protein kinase kinase kinase 14
• Synonyms
  • NIK
  • HSNIK
  • FTDCR1B
  • HS
• Synonyms name
  • serine/threonine protein-kinase
• GenBank acession
  • Y10256
• Locus
  17q21.31
• Discovery year
  2000-08-11
• Entrez gene record
  9020
• Pubmed identfication
  • 9020361
• RefSeq identity
  • NM_003954
• Classification
  • Mitogen-activated protein kinase kinase kinases
• VEGA ID
  OTTHUMG00000180364
• Locus Specific Databases
  • LRG_1222

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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