Caspase Inhibitor Negative Control (Cathepsin B Inhibitor) (Z-FA-FMK)

Description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Isotype or positive controls by peptides, antibodies and deactivated samples. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Negative control peptides or isotypes available of the different species.
Gene

CTS protease activity also measured by zymograph electrophoresis of Cathepsins. This cathepsin is supplied in 1.

Gene target

Caspase Inhibitor Cathepsin Inhibitor Z-FA-FMK
Gene symbol

PSMB7, PLA2G4F, HLA-Z, FXN, FANCD2, FANCA, ZNF276, SNU13
Short name

Caspase Inhibitor Negative Control (Cathepsin B Inhibitor) (Z-FA-FMK)
Technique

Negative, Control, controls, negatif
Alternative name

caspase suppressor Negative reference (Cathepsin B suppressor) (Z-FA-FMK)
Alternative technique

controls
Tissue

control

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042

Identity

HGNC:3585
Gene

FANCD2
Long gene name

FA complementation group D2
Synonyms gene
- FACD
- FANCD
Synonyms gene name
- Fanconi anemia complementation group D2
Synonyms
- FAD
- FA-D2
GenBank acession
- AF340183
Locus

3p25.3
Discovery year

1996-01-04
Entrez gene record

2177
Pubmed identfication
Classification
- FA complementation groups
- Armadillo like helical domain containing
VEGA ID

OTTHUMG00000128670
Locus Specific Databases

Identity

HGNC:7819
Gene

SNU13
Long gene name

small nuclear ribonucleoprotein 13
Synonyms gene
- SSFA1
- NHP2L1
Synonyms gene name
- non-histone chromosome protein 2 (S. cerevisiae)-like 1
- sperm specific antigen 1
- NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
- SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
Synonyms
- FA-1
- SPAG12
- SNRNP15-5
- 15.5K
Synonyms name
- small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)
Locus

22q13.2
Discovery year

1995-06-14
Entrez gene record

4809
Pubmed identfication
RefSeq identity
- NM_001003796
Classification
- U4/U6 small nuclear ribonucleoprotein
- U3 small nucleolar ribonucleoprotein
VEGA ID

OTTHUMG00000151189
Locus Specific Databases
- LRG_1102

Name

Negative Staining
Concept

Scope note: The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.
Tree numbers
- E01.370.225.500.620.670.520
- E01.370.225.750.600.670.520
- E05.200.500.620.670.520
- E05.200.750.600.670.520
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data