HLA-DR1 monoclonal antibody

• Catalog number
  1P-435-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human HLA-DR1, Clone: MEM-267
• Antigen
  HLA-DR1 (empty)
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  MEM-267
• Applications
  WB, FC, ELISA
• Immunogen
  Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
• Format conjugation
  PE
• Specificity
  The antibody MEM-267 specifically binds to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages). _x000D_
• Research area
  MHC (Major Histocompatibility Complex) and Related Antigens (Human)
• Concentration
  0.1 mg/ml
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human HLA-DR1, Clone: MEM-267 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Potolicchio I, Chitta S, Xu X, Fonseca D, Crisi G, Horejsi V, Strominger JL, Stern LJ, Raposo G, Santambrogio L: Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC. J Immunol. 2005 Oct 15;175(8):4935-47. _x000D_ , *Carven GJ, Chitta S, Hilgert I, Rushe MM, Baggio RF, Palmer M, Arenas JE, Strominger JL, Horejsi V, Santambrogio L, Stern LJ: Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding. J Biol Chem. 2004 Apr 16;279(16):16561-70._x000D_ _x000D_
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  HLA-DR1   monoclonal  
• Gene symbol
  HLA-DPA2, HLA-DOA, HLA-DQA1, HLA-N, HLA-DQA2, HLA-DPB1, HLA-DQB2, HLA-W, HLA-DRA, HLA-S
• Short name
  Anti-HLA-DR1 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2b
• Alternative name
  Mouse Monoclonal to HLA-DR1 (empty)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4939
• Gene
  HLA-DPA2
• Long gene name
  major histocompatibility complex, class II, DP alpha 2 (pseudogene)
• Synonyms gene
  • HLA-DP2A
• GenBank acession
  • X01634
• Locus
  6p21.32
• Discovery year
  1986-01-01
• Entrez gene record
  646702
• Pubmed identfication
  • 6597088
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031061
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4936
• Gene
  HLA-DOA
• Long gene name
  major histocompatibility complex, class II, DO alpha
• Synonyms gene
  • HLA-DZA
  • HLA-DNA
• Synonyms
  • HLA-D0-alpha
• GenBank acession
  • M31525
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3111
• Pubmed identfication
  • 2370084
• RefSeq identity
  • NM_002119
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031211
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4942
• Gene
  HLA-DQA1
• Long gene name
  major histocompatibility complex, class II, DQ alpha 1
• Synonyms gene
  • HLA-DQA
• Synonyms
  • CELIAC1
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3117
• RefSeq identity
  • NM_002122
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031106
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:19406
• Gene
  HLA-N
• Long gene name
  major histocompatibility complex, class I, N (pseudogene)
• Synonyms
  • HLA-30
• GenBank acession
  • M96329
• Locus
  6p22.1
• Discovery year
  2002-10-23
• Entrez gene record
  267014
• Pubmed identfication
  • 10452889
  • 1517563
• RefSeq identity
  • NG_009940
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031167
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4943
• Gene
  HLA-DQA2
• Long gene name
  major histocompatibility complex, class II, DQ alpha 2
• Synonyms gene
  • HLA-DXA
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3118
• RefSeq identity
  • NM_020056
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031108
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4940
• Gene
  HLA-DPB1
• Long gene name
  major histocompatibility complex, class II, DP beta 1
• Synonyms gene
  • HLA-DP1B
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3115
• RefSeq identity
  • NM_002121
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031076
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4945
• Gene
  HLA-DQB2
• Long gene name
  major histocompatibility complex, class II, DQ beta 2
• Synonyms gene
  • HLA-DXB
• GenBank acession
  • M83890
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3120
• Pubmed identfication
  • 2564844
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031125
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:23425
• Gene
  HLA-W
• Long gene name
  major histocompatibility complex, class I, W (pseudogene)
• Synonyms gene
  • HLA-80
• Synonyms gene name
  • HLA-80 pseudogene
• GenBank acession
  • M96334
• Locus
  6p22.1
• Discovery year
  2004-01-16
• Entrez gene record
  352966
• Pubmed identfication
  • 10557312
  • 1517563
• RefSeq identity
  • NG_015995
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031242
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:4947
• Gene
  HLA-DRA
• Long gene name
  major histocompatibility complex, class II, DR alpha
• Synonyms gene
  • HLA-DRA1
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3122
• RefSeq identity
  • NM_019111
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031269
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:19395
• Gene
  HLA-S
• Long gene name
  major histocompatibility complex, class I, S (pseudogene)
• Synonyms
  • HLA-17
• GenBank acession
  • M96339
• Locus
  6p21.33
• Discovery year
  2002-10-23
• Entrez gene record
  267015
• Pubmed identfication
  • 10452889
  • 1517563
• RefSeq identity
  • NG_009941
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031178
• Locus Specific Databases
  • IMGT/HLA Database

MeSH Data

• Name
  Blood Grouping and Crossmatching
• Concept
  Scope note: Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
• Tree numbers
  • E01.370.225.625.120
  • E01.370.225.812.385.120
  • E05.200.625.120
  • E05.200.812.385.120
  • E05.478.594.385.120
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

Similar products