Ro 20-1724, PDE4 inhibitor

• Catalog number
  SIH-527-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  29925-17-5
• Description
  PDE4 inhibitor
• Molecular weight
  278,3 g/mol
• Primary research fields
  Cell signaling
• Other name
  B8279, 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, Ro 20 1724, RO 20-1724, 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C15H22N2O3
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  Soluble in DMSO (200 mg/ml) or ethanol (40 mg/ml)
• Physical appearance
  White powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  5087
• Scientific context
  See included datasheet or contact our support service
• Bibliography
  Refer to NCBI PubMed
• Release date
  30/Aug/2016
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Ro 20-1724 (SIH-527), a PDE4 inhibitor. CAS #: 29925-17-5. Molecular Formula: C15H22N2O3. Molecular Weight: 278.3 g/mol. Chemical structure of Ro 20-1724, a PDE4 inhibitor (SIH-527). CAS # 29925-17-5. Molecular Formula: C15H22N2O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  20-1724   PDE4   inhibitor  
• Gene symbol
  PIRC103, SNORD114-20, SNORD116-20, IGLVI-20, PIRC104, IGHV3-20, SNORD115-20
• Short name
  Ro 20-1724, PDE4 inhibitor
• Alternative name
  Ro 20-1724, PDE4 suppressor

Gene info

• Identity
  HGNC:37607
• Gene
  PIRC103
• Long gene name
  piwi-interacting RNA cluster 103
• Locus
  20
• Discovery year
  2009-11-05
• Entrez gene record
  100313901
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33008
• Gene
  SNORD114-20
• Long gene name
  small nucleolar RNA, C/D box 114-20
• Synonyms
  • 14q(II-20)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767598
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003213.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33086
• Gene
  SNORD116-20
• Long gene name
  small nucleolar RNA, C/D box 116-20
• Synonyms
  • HBII-85-20
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033431
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003334
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5934
• Gene
  IGLVI-20
• Long gene name
  immunoglobulin lambda variable (I)-20 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-20
  • immunoglobulin lambda variable (I)-20 pseudogene
• Synonyms
  • IGLV(I)-20
• GenBank acession
  • D87007
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28769
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151242

Gene info

• Identity
  HGNC:37608
• Gene
  PIRC104
• Long gene name
  piwi-interacting RNA cluster 104
• Locus
  20
• Discovery year
  2009-11-05
• Entrez gene record
  100313801
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:5585
• Gene
  IGHV3-20
• Long gene name
  immunoglobulin heavy variable 3-20
• GenBank acession
  • M99657
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28445
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152285

Gene info

• Identity
  HGNC:33039
• Gene
  SNORD115-20
• Long gene name
  small nucleolar RNA, C/D box 115-20
• Synonyms
  • HBII-52-20
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033460
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003312.1
• Classification
  • Small nucleolar RNAs, C/D box

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