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anti-PMS2 Antibody

anti-PMS2 Antibody is available 1 time from Biovision labs

3455-100 | anti-PMS2 Antibody size: PMS2 Antibody | 376.74 USD

Catalog number 3455-100
Supplier Biovision
Price 376.74 USD
Size PMS2 Antibody
1. Gene info
Identity 9122
Gene PMS2
Long gene name PMS1 homolog 2, mismatch repair system component
Synonyms gene
  • PMSL2
Synonyms gene name
  • postmeiotic segregation increased (S. cerevisiae) 2
  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
  • PMS1 homolog 2, mismatch repair protein
Synonyms
  • H_DJ0042M02.9
  • HNPCC4
  • MLH4
Locus 7p22.1
Discovery year 1994-12-13
Entrez gene record 5395
Pubmed identfication
  • 8072530
RefSeq identity
  • NM_000535
Classification
  • MutL homologs
Havana BLAST/BLAT OTTHUMG00000023135
Locus Specific Databases
  • Hereditary Non-Polyposis Colorectal Cancer, HNPCC
  • Global Variome shared LOVD
  • PMS2 database at LOVD-China
  • LRG_161
Product images
    #0#.jpegPMS2 Antibody
Target of this antibody: PMS2
Alternative names of antibody target: HNPCC4 , PMS2CL , PMSL2 , DNA mismatch repair gene homologue H_DJ0042M02.9
Background information: Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10-45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to sμggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, mouse, rat
Immunogene sequence: Synthetic peptide surrounding amino acid 846 of human PMS2
Concentration of antibody: 0.5 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot, Immunohistochemistry
Recommended usage: Western blotting (0.5-4 µg/ml), immunoprecipitation (10-20 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetPMS2
Short name anti-PMS2 Antibody
Technique Antibody, anti
Alternative name antibody to-PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (Antibody to)
Alternative technique antibodies
Alternative to gene target PMS2 postmeiotic segregation increased 2 (S. cerevisiae), HNPCC4 and PMS2CL and PMSL2, PMS2 and IDBG-7921 and ENSG00000122512 and 5395, MutSalpha complex binding, nuclei, Pms2 and IDBG-259679 and ENSMUSG00000079109 and 18861, PMS2 and IDBG-640975 and ENSBTAG00000007364 and 527039
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anti-PMS2 Antibody | Technique alternative | 01012192339
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