A Potent inhibitor of protein phosphatases 1 and 2A in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T-cell hybridomas.
Is this a salt?
Is it cell-permeable?
DMSO (>1 mg/ml) and EtOH (>1 mg/ml)
Maximum time for storage
Protect from moisture. Tumor promoter
For cells, cell lines and tissues in culture till half confluency.
Okadaic acid for activation
Okadaic acid to measure cellular activation