2-APB, TRP blocker

• Catalog number
  SIH-316-250MG
• Price
  Please ask
• Size
  250 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  524-95-8
• Description
  TRP blocker
• Molecular weight
  225,1 g/mol
• Primary research fields
  Neuroscience, Ion Channels, Transient Receptor Potential Channels
• Other name
  2-Aminoethoxydiphenylborane
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C14H16BNO
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 100 mM in DMSO and to 10 mM in ethanol
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
• PubChem number
  1598
• Scientific context
  2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
• Bibliography
  1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329 2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328. 3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
• Release date
  16-May-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of 2-APB (SIH-316), a TRP blocker. CAS #: 524-95-8. Molecular Formula: C14H16BNO. Molecular Weight: 225.1 g/mol. Chemical structure of 2-APB, a TRP blocker (SIH-316). CAS # 524-95-8. Molecular Formula: C14H16BNO.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.25
• Other related products

• Gene target
  2-APB   TRP   blocker  
• Gene symbol
  TRP-AGG2-2, TRP-AGG2-4, RNPEP, TRP-TGG3-2, TRP-CGG1-2, TRP-AGG2-8, TRP-AGG2-7, TRP-TGG3-3, TRP-AGG2-3, TRP-AGG2-6
• Short name
  2-APB, TRP blocker
• Alternative name
  2-APB, L-tryptophan blocker

Gene info

• Identity
  HGNC:34786
• Gene
  TRP-AGG2-2
• Long gene name
  tRNA-Pro (anticodon AGG) 2-2
• Synonyms gene
  • TRNAP13
  • TRP-AGG2-7
• Synonyms gene name
  • transfer RNA proline 13 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-7
  • transfer RNA-Pro (AGG) 2-2
• Synonyms
  • tRNA-Pro-AGG-2-2
• GenBank acession
  • HG983984
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189223
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34631
• Gene
  TRP-AGG2-4
• Long gene name
  tRNA-Pro (anticodon AGG) 2-4
• Synonyms gene
  • TRNAP6
  • TRP-AGG2-2
• Synonyms gene name
  • transfer RNA proline 6 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-2
  • transfer RNA-Pro (AGG) 2-4
• Synonyms
  • tRNA-Pro-AGG-2-4
• GenBank acession
  • HG983979
• Locus
  11q13.5
• Discovery year
  2008-08-29
• Entrez gene record
  100189072
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:10078
• Gene
  RNPEP
• Long gene name
  arginyl aminopeptidase
• Synonyms gene name
  • arginyl aminopeptidase (aminopeptidase B)
• Synonyms
  • APB
• Synonyms name
  • aminopeptidase B
• GenBank acession
  • BC001064
• Locus
  1q32.1
• Discovery year
  1993-04-15
• Entrez gene record
  6051
• Pubmed identfication
  • 9533033
  • 10467730
• RefSeq identity
  • NM_020216
• Classification
  • Aminopeptidases
  • MicroRNA protein coding host genes
  • M1 metallopeptidases
• VEGA ID
  OTTHUMG00000035866

Gene info

• Identity
  HGNC:34648
• Gene
  TRP-TGG3-2
• Long gene name
  tRNA-Pro (anticodon TGG) 3-2
• Synonyms gene
  • TRNAP7
  • TRP-TGG3-1
• Synonyms gene name
  • transfer RNA proline 7 (anticodon UGG)
  • transfer RNA-Pro (TGG) 3-1
  • transfer RNA-Pro (TGG) 3-2
• Synonyms
  • tRNA-Pro-TGG-3-2
• GenBank acession
  • HG983997
• Locus
  14q11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189088
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34784
• Gene
  TRP-CGG1-2
• Long gene name
  tRNA-Pro (anticodon CGG) 1-2
• Synonyms gene
  • TRNAP12
• Synonyms gene name
  • transfer RNA proline 12 (anticodon CGG)
  • transfer RNA-Pro (CGG) 1-2
• Synonyms
  • tRNA-Pro-CGG-1-2
• GenBank acession
  • HG983991
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189221
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34862
• Gene
  TRP-AGG2-8
• Long gene name
  tRNA-Pro (anticodon AGG) 2-8
• Synonyms gene
  • TRNAP18
  • TRP-AGG2-6
• Synonyms gene name
  • transfer RNA proline 18 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-6
  • transfer RNA-Pro (AGG) 2-8
• Synonyms
  • tRNA-Pro-AGG-2-8
• GenBank acession
  • HG983983
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189296
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34698
• Gene
  TRP-AGG2-7
• Long gene name
  tRNA-Pro (anticodon AGG) 2-7
• Synonyms gene
  • TRNAP9
  • TRP-AGG2-5
• Synonyms gene name
  • transfer RNA proline 9 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-5
  • transfer RNA-Pro (AGG) 2-7
• Synonyms
  • tRNA-Pro-AGG-2-7
• GenBank acession
  • HG983982
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189136
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34903
• Gene
  TRP-TGG3-3
• Long gene name
  tRNA-Pro (anticodon TGG) 3-3
• Synonyms gene
  • TRNAP19
  • TRP-TGG3-2
• Synonyms gene name
  • transfer RNA proline 19 (anticodon UGG)
  • transfer RNA-Pro (TGG) 3-2
  • transfer RNA-Pro (TGG) 3-3
• Synonyms
  • tRNA-Pro-TGG-3-3
• GenBank acession
  • HG983998
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189335
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34840
• Gene
  TRP-AGG2-3
• Long gene name
  tRNA-Pro (anticodon AGG) 2-3
• Synonyms gene
  • TRNAP15
  • TRP-AGG2-8
• Synonyms gene name
  • transfer RNA proline 15 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-8
  • transfer RNA-Pro (AGG) 2-3
• Synonyms
  • tRNA-Pro-AGG-2-3
• GenBank acession
  • HG983985
• Locus
  7q32.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189276
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:12331
• Gene
  TRP-AGG2-6
• Long gene name
  tRNA-Pro (anticodon AGG) 2-6
• Synonyms gene
  • TRNP1
  • TRP2
  • TRNAP2
  • TRP-AGG2-4
• Synonyms gene name
  • tRNA proline 2
  • transfer RNA proline 2 (anticodon UGG)
  • transfer RNA proline 2 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-4
  • transfer RNA-Pro (AGG) 2-6
• Synonyms
  • tRNA-Pro-AGG-2-6
• GenBank acession
  • HG983981
• Locus
  14q11.2
• Discovery year
  1989-06-30
• Entrez gene record
  7218
• Pubmed identfication
  • 3557125
• Classification
  • Cytoplasmic transfer RNAs

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