LH-846

Alternative_name

N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Description

LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. LH846 increases circadian period by 10 hours in human U2OS cells.
CAS Number

639052-78-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₆H₁₃ClN₂OS
Molecular Weight

316.81
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A casein kinase (CK) 1δ inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

851474
PubChem CID Link
SMILES

CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
InChi

InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
InChi Key

DYHAMRNAHTWYKY-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes