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Synonyms
LGALS4, L36LBP, Gal-4, Antigen NY-CO-27, Lactose-binding lectin 4
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Alternative_names
LGALS4, L36LBP, Gal-4, Antigen NY-CO-27, Lactose-binding lectin 4
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Description
Implicated in modulating cell-cell and cell-matrix interactions
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Recombinant
Yes
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Source
HEK293 cells
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Purity by SDS PAGE
> 92%
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Assay
SDS-PAGE
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Endotoxin Level
< 1.0 EU per/ug
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Molecular Weight
38.6 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.4. Normally trehalose is added as protectant before lyophilization.
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Reconstitution Instructions
Reconstitute in sterile deionized water to the desired protein concentration.
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Background Information
Galectin-4 (Gal-4), also known as L36LBP (L-36 lactose-binding protein). The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Additional source
Recombinants or rec. proteins
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Group
recombinants
