ZM 306416, VEGFR kinase inhibitor

• Catalog number
  SIH-487-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  690206-97-4
• Description
  VEGFR kinase inhibitor
• Molecular weight
  333,7 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  ZM-306416
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C16H13ClFN3O2
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (TLC)
• Soluble in
  Soluble in DMSO (3 mg/ml) or ethanol (1 mg/ml)
• Physical appearance
  Off-white solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  5329006
• Scientific context
  ZM 306416 is a potent and selective VEGF receptor tyrosine kinase inhibitor. Specifically, it inhibits Flk-1 (KDR) and Flt.
• Bibliography
  1. Hennequin L.F., et al. (1999) J. Med. Chem. 42(26): 5369–5389. 2. Kawai, T., et al. (2006) Neurosci. 141(3): 1209–1216.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of ZM 306416 (SIH-487), a VEGFR kinase inhibitor. CAS #: 690206-97-4. Molecular Formula: C16H13ClFN3O2. Molecular Weight: 333.7 g/mol. Chemical structure of ZM 306416, a VEGFR kinase inhibitor (SIH-487). CAS # 690206-97-4. Molecular Formula: C16H13ClFN3O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  306416   VEGFR   kinase   inhibitor  
• Gene symbol
  FLT4, KDR
• Short name
  ZM 306416, VEGFR kinase inhibitor
• Alternative name
  ZM 306416, VEGFR phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:3767
• Gene
  FLT4
• Long gene name
  fms related receptor tyrosine kinase 4
• Synonyms gene name
  • fms-related tyrosine kinase 4
  • fms related tyrosine kinase 4
• Synonyms
  • VEGFR3
  • PCL
  • VEGFR-3
• Synonyms name
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • primary congenital lymphedema
• GenBank acession
  • X68203
• Locus
  5q35.3
• Discovery year
  1991-10-25
• Entrez gene record
  2324
• Pubmed identfication
  • 1319394
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000130931

Gene info

• Identity
  HGNC:6307
• Gene
  KDR
• Long gene name
  kinase insert domain receptor
• Synonyms gene name
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
• Synonyms
  • FLK1
  • VEGFR
  • VEGFR2
  • CD309
• Synonyms name
  • vascular endothelial growth factor receptor 2
  • fetal liver kinase 1
• GenBank acession
  • AF035121
• Locus
  4q12
• Discovery year
  1991-07-10
• Entrez gene record
  3791
• Pubmed identfication
  • 1417831
• Classification
  • Receptor tyrosine kinases
  • CD molecules
  • I-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000128734
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_1198

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